Description

Daunomycinone-D3 is a deuterated analog of the anthracycline aglycone daunomycinone, specifically labeled with three deuterium atoms. This stable isotope-labeled compound is a critical reference standard and intermediate for advanced analytical and metabolic research in pharmaceutical development. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors.

Application

• Internal Standard for LC-MS/MS: Used as a high-purity internal standard for the precise quantification of daunomycinone and related anthracyclines in bioanalytical studies, ensuring accurate pharmacokinetic and metabolic data.
• Metabolic Pathway Tracing: Employed in drug metabolism and disposition (DMPK) studies to trace and elucidate metabolic pathways and stability of anthracycline-based pharmaceuticals.
• Pharmaceutical Impurity Profiling: Serves as a critical reference material for identifying and quantifying process-related impurities and degradants in active pharmaceutical ingredient (API) batches.
• Deuterated Synthetic Intermediate: Acts as a key building block in the synthesis of more complex deuterated anthracycline drug candidates for enhanced metabolic properties.
• Quality Control & Method Development: Essential for developing and validating robust analytical methods (HPLC, UPLC) in compliance with ICH guidelines within quality control laboratories.

Basic Information

Product Name	Daunomycinone-D3
CAS No.	1217860-39-3
Molecular Formula	C21H15D3O8
Molecular Weight	401.37 g/mol (approx.)
Synonyms	(8S,10S)-8-Acetyl-10-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-1-(trideuteriomethoxy)-9,10-dihydro-7H-tetracene-5,12-dione; Daunomycinone (trideuteriomethoxy-); 1-(Trideuteriomethoxy)daunomycinone; Deuterated Daunomycinone; Daunomycinone-d3; 7,9,11-Trihydroxy-4-methoxy-d3-8,10-dihydro-1H-anthra[1,2-b]oxanthene-5,12-dione
EINECS	Contact for details

Quality Control

Our Daunomycinone-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, assay (by HPLC), isotopic enrichment (by MS), and related substance analysis. We support compliance with relevant pharmacopeial and ICH guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (by NMR)	Conforms
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.