Description

(R)-Phenylephrine-D3 Hydrochloride CAS NO 1217858-50-8 is a high-purity, isotopically labeled deuterated standard of the adrenergic receptor agonist phenylephrine. This compound is essential for ensuring analytical accuracy and reliability in quantitative bioanalysis and pharmacokinetic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development and validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the precise quantification of phenylephrine in complex biological matrices such as plasma, serum, and urine.
• Pharmacokinetic and Metabolism Studies: Enables accurate tracing and measurement of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Used to develop, optimize, and validate robust, sensitive, and specific analytical methods compliant with FDA, EMA, and ICH guidelines.
• Doping Control Analysis: Employed in sports anti-doping laboratories for the definitive identification and quantification of phenylephrine and related substances.
• Forensic Toxicology: Aids in the accurate detection and measurement of phenylephrine in forensic investigations.
• Pharmaceutical Quality Control: Supports impurity profiling and stability-indicating assay methods for drug substance and product analysis.

Basic Information

Product Name	(R)-Phenylephrine-D3 Hydrochloride
CAS No.	1217858-50-8
Molecular Formula	C9H10D3NO2•HCl
Molecular Weight	207.69 g/mol
Synonyms	(R)-(-)-Phenylephrine-d3 HCl; (1R)-1-(3-Hydroxyphenyl)-2-(methylamino)ethanol-d3 hydrochloride; L-Phenylephrine-d3 hydrochloride; (-)-m-Synephrine-d3 hydrochloride; Phenylephrine (D3, hydrochloride); Deuterated Phenylephrine HCl; Isotopic Labeled Phenylephrine Internal Standard
EINECS	Contact for details

Quality Control

Our (R)-Phenylephrine-D3 Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, chemical purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.