Description

D-(-)-4-Hydroxyphenyl-D4-Glycine is a deuterium-labeled derivative of the amino acid D-4-hydroxyphenylglycine, a key chiral building block. This isotopically labeled compound is essential for advanced analytical and research applications where precise molecular tracking is required. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and manufacturers of reference standards for applications in drug metabolism studies (DMPK), proteomics, and as an internal standard in mass spectrometry.

Application

• Pharmaceutical Research & Development: Serves as a critical internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and LC-MS/MS for the quantitative analysis of D-4-hydroxyphenylglycine and related compounds in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used as a stable isotope-labeled tracer in absorption, distribution, metabolism, and excretion (ADME) studies to elucidate metabolic pathways.
• Proteomics and Metabolomics: Employed in isotope-coded affinity tag (ICAT) and other labeling techniques for comparative protein and metabolite profiling.
• Reference Standard Manufacturing: A high-purity material for the preparation of certified reference standards (CRS) and working standards used in quality control laboratories.
• Synthetic Intermediate: Acts as a deuterated building block in the synthesis of more complex labeled molecules for research purposes.
• Analytical Method Development: Crucial for developing and validating highly sensitive and specific analytical methods in regulatory environments (e.g., FDA, EMA).

Basic Information

Product Name	D-(-)-4-Hydroxyphenyl-D4-Glycine
CAS No.	1217854-79-9
Molecular Formula	C8H5D4NO3
Molecular Weight	171.18 g/mol (for deuterated form)
Synonyms	(R)-2-Amino-2-(4-hydroxyphenyl)acetic-2,3,5,6-d4 Acid; D-4-Hydroxyphenyl-d4-glycine; (R)-4-Hydroxyphenyl-d4-glycine; D-(-)-p-Hydroxyphenyl-d4-glycine; (R)-Amino(4-hydroxyphenyl-d4)acetic Acid; Deuterated D-HPG; D-HPG-d4; D-PHPG-d4
EINECS	Contact for details

Quality Control

Our D-(-)-4-Hydroxyphenyl-D4-Glycine is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical and isotopic purity, NMR for structural confirmation, and MS for identity verification. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or quality standards. Specifications can meet the requirements for use as a reference material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions or under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Specific range provided on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.