Description

[2H3]- Vincristine Sulfate is a deuterium-labeled analog of the potent vinca alkaloid antineoplastic agent, vincristine sulfate. This stable isotope-labeled compound is essential for advanced pharmacokinetic and metabolic studies, providing critical internal standards for mass spectrometry-based analytical methods. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in oncology drug development and bioanalytical research.

Application

• As a stable isotope-labeled internal standard for the precise quantification of vincristine in biological matrices (e.g., plasma, serum) using LC-MS/MS.
• For conducting advanced pharmacokinetic (PK) and pharmacodynamic (PD) studies in preclinical and clinical research.
• In drug metabolism and disposition (DMPK) investigations to elucidate metabolic pathways and bioavailability.
• Use in bioanalytical method development and validation to ensure accuracy, precision, and regulatory compliance (e.g., FDA, EMA).
• Supporting generic drug development for bioequivalence studies of vincristine sulfate formulations.
• Application in academic research focusing on the mechanisms of action and resistance of vinca alkaloids.

Basic Information

Product Name	[2H3]- Vincristine Sulfate
CAS No.	1217854-24-4
Molecular Formula	C46H53D3N4O10 · H2SO4
Molecular Weight	Approx. 923.06 g/mol (Contact for exact details)
Synonyms	Deuterated Vincristine Sulfate; Vincristine-d3 Sulfate; 22-Oxovincaleukoblastine-d3 Sulfate; Leurocristine-d3 Sulfate; LCR-d3 Sulfate; VCR-d3 Sulfate; [2H3]-Leurocristine Sulfate; Oncovin-d3 Sulfate
EINECS	Contact for details

Quality Control

Our [2H3]- Vincristine Sulfate is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic purity (deuterium incorporation), and chromatographic profile. We adhere to relevant industry standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Isotopic Purity (deuterium incorporation)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.