Description

(2S)-4,4,4-Trideuterio-2-(2-Oxopyrrolidin-1-Yl)Butanamide is a high-purity, isotopically labeled chemical building block of significant interest in advanced research and development. This compound is specifically valued for its role as a deuterated analog in metabolic and pharmacokinetic studies, providing enhanced analytical precision. It is primarily utilized by pharmaceutical researchers and analytical chemists working on drug discovery, development of novel active pharmaceutical ingredients (APIs), and the synthesis of complex organic molecules.

Application

• Pharmaceutical Research & Development: As a deuterated intermediate in the synthesis of novel drug candidates, particularly for metabolic stability studies and tracer applications.
• Isotope Labeling: Serving as a crucial building block for incorporating deuterium atoms into target molecules to study reaction mechanisms and metabolic pathways.
• Analytical Reference Standard: Used as an internal standard in quantitative mass spectrometry (LC-MS, GC-MS) for accurate bioanalysis and pharmacokinetic profiling.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to investigate the impact of deuterium substitution on the biological activity and physicochemical properties of lead compounds.
• Chemical Synthesis: As a specialized reagent for the preparation of labeled pyrrolidinone derivatives and other complex heterocyclic compounds.

Basic Information

Product Name	(2S)-4,4,4-Trideuterio-2-(2-Oxopyrrolidin-1-Yl)Butanamide
CAS No.	1217851-16-5
Molecular Formula	C8H11D3N2O2
Molecular Weight	173.22 g/mol
Synonyms	(2S)-2-(2-Oxopyrrolidin-1-yl)-4,4,4-trideuteriobutanamide; (S)-2-(2-Oxopyrrolidin-1-yl)-4,4,4-trideuteriobutanamide; 4,4,4-Trideuterio-2-(2-oxo-1-pyrrolidinyl)butanamide, (2S)-; Deuterated Pregabalin Intermediate; (S)-4,4,4-Trideuterio-2-(2-oxopyrrolidin-1-yl)butanamide; 1-Pyrrolidineacetamide, α-amino-4,4,4-trideutero-γ-oxo-, (αS)-; (2S)-2-(2-Oxopyrrolidin-1-yl)-4,4,4-trideuteriobutyramide
EINECS	Contact for details

Quality Control

Our (2S)-4,4,4-Trideuterio-2-(2-Oxopyrrolidin-1-Yl)Butanamide is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and Mass Spectrometry, to confirm chemical and isotopic identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.