Description

Fmoc-3-Exo-Aminobicyclo[2.2.1]Hept-5-Ene-2-Exo-Carboxylic Acid CAS NO 1217848-39-9 is a specialized, high-purity building block featuring a rigid norbornene scaffold with orthogonal Fmoc-protected amine and carboxylic acid functional groups. This compound is critical for introducing conformational constraints and unique three-dimensional geometry into synthetic peptides and peptidomimetics. It is primarily utilized by researchers and process chemists in pharmaceutical development, agrochemical discovery, and advanced materials science for creating novel bioactive compounds.

Application

• Peptide Synthesis: Serves as a constrained, non-natural amino acid analog for introducing rigid secondary structures (e.g., β-turns, helices) in solid-phase peptide synthesis (SPPS).
• Pharmaceutical R&D: A key intermediate in the design and synthesis of novel drug candidates targeting proteases, GPCRs, and other protein-protein interaction interfaces.
• Peptidomimetic Libraries: Used in combinatorial chemistry to generate focused libraries of conformationally restricted molecules for high-throughput screening.
• Bioconjugation & Probe Development: The carboxylic acid moiety allows for site-specific conjugation to labels, tags, or other molecules to create chemical probes.
• Agrochemical Research: Employed in the synthesis of bioactive peptides and mimetics with potential insecticidal or fungicidal activity.
• Materials Science: Can be incorporated into specialty polymers or dendrimers to impart specific mechanical or chemical properties.

Basic Information

Product Name	Fmoc-3-Exo-Aminobicyclo[2.2.1]Hept-5-Ene-2-Exo-Carboxylic Acid
CAS No.	1217848-39-9
Molecular Formula	C24H23NO4
Molecular Weight	389.45 g/mol
Synonyms	Fmoc-3-exo-Amino-2-exo-carboxybicyclo[2.2.1]hept-5-ene; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-exo-aminobicyclo[2.2.1]hept-5-ene-2-exo-carboxylic Acid; 2-[[(9-Fluorenylmethoxy)carbonyl]amino]bicyclo[2.2.1]hept-5-ene-3-carboxylic Acid; Fmoc-Abn-OH; Fmoc-3-Amino-2-carboxynorborn-5-ene; N-Fmoc-3-amino-2-norbornene-5-carboxylic acid; (1R,2S,3S,4R)-3-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our Fmoc-3-Exo-Aminobicyclo[2.2.1]Hept-5-Ene-2-Exo-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.