Description

Cis (1S,4S)-1-Azido-4-(3,4-Dichlorophenyl)-1,2,3,4-Tertahydro-Naphthalene-D4 is a high-purity, deuterated isotopologue of a complex organic intermediate. This compound is of significant value for research and development, particularly in the fields of medicinal chemistry and pharmacology, where it serves as a critical building block or analytical standard. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and advanced chemical synthesis facilities working on novel drug discovery programs and metabolic studies.

Application

• Pharmaceutical Intermediate: A key deuterated synthon in the research-scale synthesis of novel therapeutic candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Metabolic Pathway Tracer: Utilized in pharmacokinetic and drug metabolism studies (DMPK) as a stable isotope-labeled internal standard for mass spectrometry (LC-MS/MS) to enhance analytical accuracy and sensitivity.
• Mechanistic Probe: Employed in chemical biology to investigate reaction mechanisms and biological pathways where the deuterium label provides crucial insights.
• Reference Standard: Serves as a certified reference material (CRM) for the quality control and quantification of its non-deuterated counterpart in active pharmaceutical ingredient (API) development.
• Isotope Effect Studies: Used to study kinetic isotope effects (KIEs) in chemical and enzymatic reactions, aiding in the design of more effective and stable drug molecules.

Basic Information

Product Name	Cis (1S,4S)-1-Azido-4-(3,4-Dichlorophenyl)-1,2,3,4-Tertahydro-Naphthalene-D4
CAS No.	1217836-22-0
Molecular Formula	C16H10D4Cl2N4
Molecular Weight	345.25 g/mol (approx.)
Synonyms	(1S,4S)-1-Azido-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalene-d4; 1-Azido-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalene-d4 (cis-); Deuterated Cis-1-Azido-4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydronaphthalene; Tetralin-d4 azide derivative; Isotopically Labeled Tetralin Intermediate; 3,4-Dichlorophenyl-substituted deuterated tetralin azide; Stable Isotope-Labeled Pharmaceutical Building Block
EINECS	Contact for details

Quality Control

Our Cis (1S,4S)-1-Azido-4-(3,4-Dichlorophenyl)-1,2,3,4-Tertahydro-Naphthalene-D4 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 13C), HPLC, and mass spectrometry, to ensure high chemical purity, isotopic enrichment, and stereochemical integrity. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is light-sensitive and should be handled under controlled conditions to prevent decomposition. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D-content, MS)	≥ 98 atom % D
Chemical Purity (NMR)	≥ 97%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.