Description

Methyl (3R)-2-(Chloroacetyl)-2,3,4,9-Tetrahydro-1H-β-Carboline-3-Carboxylate is a high-purity, chiral synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of complex molecules, particularly those targeting neurological and oncological pathways. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for creating novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the multi-step synthesis of complex drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used as a scaffold or building block for constructing novel β-carboline and tetrahydroisoquinoline analogs for biological screening.
• Process Chemistry Development: Serves as a standard or reference material for optimizing asymmetric synthesis routes and scaling up API manufacturing processes.
• Academic & Institutional R&D: Employed in university and research institute laboratories for studying synthetic methodology and structure-activity relationships (SAR).
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development programs for global clients.
• Fine Chemical Synthesis: Utilized in the production of specialized, high-value chemicals for non-pharmaceutical applications requiring specific chirality.

Basic Information

Product Name	Methyl (3R)-2-(Chloroacetyl)-2,3,4,9-Tetrahydro-1H-β-Carboline-3-Carboxylate
CAS No.	1217811-48-7
Molecular Formula	C15H15ClN2O3
Molecular Weight	306.75 g/mol
Synonyms	(3R)-Methyl 2-(2-chloroacetyl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylate; Methyl (R)-2-(chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate; (R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate; 1H-β-Carboline-3-carboxylic acid, 2-(chloroacetyl)-1,2,3,4-tetrahydro-, methyl ester, (3R)-; Chiral β-Carboline Ester; Tetrahydro-β-carboline Derivative
EINECS	Contact for details

Quality Control

Our Methyl (3R)-2-(Chloroacetyl)-2,3,4,9-Tetrahydro-1H-β-Carboline-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.