Description

Tiagabine-D6 Hydrochloride Solution is a stable isotope-labeled internal standard of the anticonvulsant drug Tiagabine, specifically designed for quantitative analytical applications. This high-purity reference material is essential for ensuring the accuracy and reliability of mass spectrometry-based methods in pharmaceutical research and development. It is primarily used by analytical chemists and researchers in pharmaceutical, contract research (CRO), and forensic toxicology laboratories for method development, validation, and routine drug level monitoring.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the precise quantification of Tiagabine in biological matrices (plasma, serum, urine) using LC-MS/MS and GC-MS.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion in clinical and preclinical studies.
• Therapeutic Drug Monitoring (TDM): Used in assays to monitor Tiagabine concentrations in patient samples to optimize dosing and ensure therapeutic efficacy while minimizing side effects.
• Drug Metabolism and Disposition Research: Facilitates studies on the metabolic pathways and stability of Tiagabine.
• Forensic and Clinical Toxicology: Aids in the confirmatory identification and quantification of Tiagabine in complex samples for diagnostic or legal purposes.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and assay development for drug substance and product quality assurance.

Basic Information

Product Name	Tiagabine-D6 Hydrochloride Solution
CAS No.	1217808-68-8
Molecular Formula	C20H19D6NO2S2·HCl
Molecular Weight	412.06 g/mol (approx.)
Synonyms	Tiagabine-d6 HCl; (R)-(-)-N-[4,4-Bis(3-methyl-2-thienyl)-3-buten-1-yl]-3-piperidinecarboxylic acid-d6 hydrochloride; Gabitril-d6 hydrochloride; NO-328-d6 hydrochloride; 3-[(1R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-en-1-yl]piperidine-3-carboxylic acid-d6 hydrochloride; Deuterated Tiagabine Hydrochloride; Tiagabine Internal Standard D6.
EINECS	Contact for details

Quality Control

Every batch of Tiagabine-D6 Hydrochloride Solution is manufactured and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, with comprehensive characterization by NMR, MS, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (by HPLC), isotopic enrichment, and concentration. Our quality system supports compliance with ISO 9001 standards, ensuring traceability and consistency for regulated laboratory environments.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended cold storage conditions (typically 2-8°C or as specified on the label). For long-term storage, solutions may be kept at -20°C. Allow the solution to equilibrate to room temperature before use and mix thoroughly.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Assay (HPLC)	≥98.0% (chemical purity)
Isotopic Purity	≥98.0 atom % D
Concentration	Typically 0.1 mg/mL or 1.0 mg/mL in solvent (e.g., Methanol, Acetonitrile)
Solvent	As specified (e.g., Methanol, Acetonitrile)
Related Substances (HPLC)	Individual unspecified impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.