Description

Trans (1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-Naphthalen-1-Ol-D4 is a high-purity, deuterium-labeled stereoisomer of a key pharmaceutical intermediate. This compound is specifically designed for use in advanced analytical and research applications where isotopic labeling is required for precise tracking and quantification. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and internal standard synthesis.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical, isotopically labeled internal standard for the accurate quantification of its non-deuterated counterpart in complex biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) pathways in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used to develop robust, sensitive, and specific analytical methods for pharmaceutical compounds in compliance with regulatory guidelines (e.g., FDA, EMA).
• Metabolite Identification and Profiling: Aids in the identification and structural elucidation of drug metabolites using mass spectrometry.
• Stable Isotope Labeling in Medicinal Chemistry: Provides a tool for mechanistic studies and for synthesizing labeled analogs for further biological evaluation.
• Quality Control and Reference Standard: Acts as a high-purity reference material for quality assurance in the production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Trans (1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-Naphthalen-1-Ol-D4
CAS No.	1217787-79-5
Molecular Formula	C₁₆H₁₁D₄Cl₂O
Molecular Weight	306.22 g/mol (approximate)
Synonyms	(1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-ol-d4; 4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthol-d4; Deuterated (1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenol; (1R,4S)-rel-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenol-d4; Trans-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthol-d4; D4-labeled THN derivative; Isotopically labeled pharmaceutical intermediate.
EINECS	Contact for details

Quality Control

Every batch of Trans (1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-Naphthalen-1-Ol-D4 is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high chemical and isotopic purity to meet the exacting standards required for analytical and research applications. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (by HPLC), isotopic enrichment, and related substances is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D4)	≥ 98 atom % D
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.