Description

7,8-Dihydro-L-Biopterin-D3 is a deuterated isotopologue of the essential cofactor 7,8-dihydro-L-biopterin, a key intermediate in the biosynthesis of tetrahydrobiopterin (BH4). This compound is of significant value for research and development, particularly in metabolic and neurological studies, where it serves as a stable, non-radioactive internal standard for precise quantification via mass spectrometry. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and diagnostic manufacturers focused on inborn errors of metabolism, neurotransmitter synthesis pathways, and biomarker analysis.

Application

• Internal Standard for LC-MS/MS: Used as a stable isotope-labeled internal standard for the accurate quantification of endogenous biopterin and related pterins in biological matrices.
• Metabolic Research: Critical for studying the tetrahydrobiopterin (BH4) synthesis and regeneration cycles, particularly in relation to phenylketonuria (PKU) and other BH4-deficient disorders.
• Neurological & Psychiatric Research: Applied in investigations of neurotransmitter (dopamine, serotonin, norepinephrine) biosynthesis where BH4 is a required cofactor.
• Diagnostic Assay Development: Employed in the development and validation of clinical diagnostic kits for measuring pterin levels in blood, urine, or dried blood spots.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Utilized in drug development programs targeting enzymes in the pterin metabolic pathway.
• Biochemical Reagent: Serves as a high-purity reference material and reagent in enzymatic assays and biochemical studies.

Basic Information

Product Name	7,8-Dihydro-L-Biopterin-D3
CAS No.	1217782-44-9
Molecular Formula	C9H11D3N5O3
Molecular Weight	242.25 g/mol
Synonyms	(6R)-2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-4(3H)-pteridinone-d3; L-erythro-7,8-Dihydrobiopterin-d3; BH2-d3; 7,8-DHBP-d3; 6-(L-erythro-1,2-Dihydroxypropyl)-7,8-dihydropterin-d3; Deuterated Dihydrobiopterin; [2,2',3,3',4,4',5,5',6,6',7,7'-d12]-7,8-Dihydro-L-biopterin (partial deuteration specified); Sepiapterin reductase substrate analog-d3
EINECS	Contact for details

Quality Control

Our 7,8-Dihydro-L-Biopterin-D3 is manufactured under strict quality control protocols to ensure high chemical and isotopic purity, critical for its use as an analytical standard. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR for deuteration level confirmation and HPLC for chemical purity assessment. Certificates of Analysis (COA) detailing batch-specific results for purity, isotopic enrichment, and identity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (Deuteration)	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.