Description

Atomoxetine-D3 HCl is a deuterated isotopologue of the selective norepinephrine reuptake inhibitor atomoxetine, where three hydrogen atoms are replaced with deuterium. This labeled compound is a critical internal standard for the precise and accurate quantification of atomoxetine in complex biological matrices using advanced analytical techniques. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, bioequivalence testing, and drug metabolism research.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a stable, non-interfering reference for the quantification of atomoxetine in plasma, serum, and urine samples.
• Pharmacokinetic and Bioanalytical Studies: Enables precise measurement of drug concentration-time profiles to determine absorption, distribution, metabolism, and excretion (ADME) parameters.
• Drug Metabolism Research (DMPK): Used in mass spectrometry-based assays to study metabolic pathways and identify metabolites without isotopic interference.
• Clinical Trial Support: Essential for bioanalytical method development and validation in support of Phase I-IV clinical trials for atomoxetine-based therapeutics.
• Forensic and Toxicology Testing: Provides high specificity and accuracy in confirmatory testing for atomoxetine in forensic applications.
• Quality Control in Pharmaceutical Manufacturing: Can be employed in analytical methods for monitoring the active pharmaceutical ingredient (API) during production.

Basic Information

Product Name	Atomoxetine-D3 HCl
CAS No.	1217776-38-9
Molecular Formula	C17H18D3NO•HCl
Molecular Weight	308.85 g/mol
Synonyms	(R)-N-Methyl-3-phenyl-3-(o-tolyloxy)propylamine-D3 hydrochloride; (R)-Tomoxetine-D3 hydrochloride; LY139603-D3; (R)-Methyl(3-phenyl-3-(o-tolyloxy)propyl)amine-D3 hydrochloride; (3R)-3-(2-Methylphenoxy)-3-phenyl-N-methylpropan-1-amine-D3 hydrochloride; Atomoxetine (D3) hydrochloride; Strattera-D3 HCl
EINECS	Contact for details

Quality Control

Our Atomoxetine-D3 HCl is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical identity, essential for reliable analytical results. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from NMR, HPLC, and LC-MS analysis. We adhere to relevant industry guidelines for reference standards to support GLP and GMP-compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (LC-MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.