Description

(1R,2S)-2-(Aminomethyl)-N,n-Bis(1,1,2,2,2-Pentadeuterioethyl)-1-Phenylcyclopropane-1-Carboxamide:Hydrochloride is a high-purity, deuterium-labeled chemical reference standard of significant value in advanced research and development. This compound is specifically designed for use as an internal standard in quantitative mass spectrometry, enabling precise and accurate analytical measurements. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and academic institutions engaged in metabolite identification, pharmacokinetic studies, and drug metabolism research.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of parent drugs and metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of pharmaceutical candidates.
• Bioanalytical Method Development: Serves as a stable, isotopically labeled reference to validate and calibrate sensitive analytical methods.
• Metabolite Profiling and Identification: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometric analysis.
• Preclinical and Clinical Research: Supports toxicology studies and clinical trials by providing reliable data on drug concentration levels.
• Pharmaceutical Impurity Testing: Can be utilized as a reference marker in stability-indicating methods for quality control.

Basic Information

Item	Detail
Product Name	(1R,2S)-2-(Aminomethyl)-N,n-Bis(1,1,2,2,2-Pentadeuterioethyl)-1-Phenylcyclopropane-1-Carboxamide:Hydrochloride
CAS No.	1217774-40-7
Molecular Formula	C17H20D10ClN3O
Molecular Weight	Contact for details
Synonyms	Deuterated (1R,2S)-2-(Aminomethyl)-N,N-Bis(2,2,2-trideuterioethyl)-1-phenylcyclopropane-1-carboxamide hydrochloride; (1R,2S)-2-(Aminomethyl)-N,N-Bis(pentadeuterioethyl)-1-phenylcyclopropanecarboxamide hydrochloride; Deuterium-labeled Cyclopropane Carboxamide Derivative; Isotopic Internal Standard 1217774-40-7; (1R,2S)-rel-2-(Aminomethyl)-N,N-bis(1,1,2,2,2-pentadeuterioethyl)-1-phenylcyclopropanecarboxamide hydrochloride
EINECS	Contact for details

Quality Control

Every batch of this deuterated standard is produced and analyzed under strict quality protocols to ensure exceptional isotopic purity and chemical identity. Our quality assurance includes comprehensive characterization by NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming batch-specific data for identity, purity (HPLC), isotopic enrichment, and other critical parameters to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.