Description

2,2,2-Trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(Imidazol-1-Ylmethyl)-1,3-Dioxolan-4-Yl]Methoxy]Phenyl]Piperazin-1-Yl]Ethanone is a deuterated derivative of a potent antifungal agent, designed for advanced research and development. This compound is a critical stable isotope-labeled standard, essential for precise pharmacokinetic, metabolic, and bioanalytical studies where accurate quantification is paramount. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on drug development and analytical method validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard in quantitative bioanalysis for method development and validation, ensuring high accuracy and reproducibility in drug concentration measurements.
• Metabolite Tracing & Pharmacokinetics (PK): Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to trace the parent drug and its metabolites, enabling detailed PK/PD modeling.
• Drug Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products during pharmaceutical development and quality control.
• Mechanistic Studies: Facilitates research into the metabolic pathways and enzymatic interactions of the parent antifungal compound.
• Reference Standard: Provides a certified, high-purity reference material for calibrating analytical instruments and ensuring regulatory compliance in GLP/GMP environments.

Basic Information

Product Name	2,2,2-Trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(Imidazol-1-Ylmethyl)-1,3-Dioxolan-4-Yl]Methoxy]Phenyl]Piperazin-1-Yl]Ethanone
CAS No.	1217766-70-5
Molecular Formula	C26H27D3Cl2N4O4
Molecular Weight	530.44 g/mol (for C26H27D3Cl2N4O4)
Synonyms	Deuterated Ketoconazole Derivative; [D3]-Ketoconazole Metabolite Standard; 1-Acetyl-4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine-d3; 2,2,2-Trideutero-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone; Ketoconazole-d3 Metabolite; (2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl 4-(1-Oxo-2,2,2-trideuteroethyl)-1-piperazinecarboxylate Derivative
EINECS	Contact for details

Quality Control

Our deuterated standards are manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR (¹H, ¹³C, ²H), High-Resolution Mass Spectrometry (HRMS), and HPLC. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment (D%), chemical purity, and confirming structural identity, supporting compliance with GLP and research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (²H NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.