Description

n-(2-Mercaptoethyl) Demecolcine is a chemically modified derivative of the natural alkaloid demecolcine, designed for advanced research and pharmaceutical development. This compound matters for its potential as a key intermediate or active moiety in the synthesis of novel therapeutic agents, particularly in targeted drug delivery systems. It is needed by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on oncology research, microtubule dynamics, and the development of prodrug strategies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel chemotherapeutic agents and targeted cancer therapies.
• Biochemical Research: Used as a research tool to study microtubule assembly and disassembly, cell cycle progression, and mechanisms of mitosis.
• Prodrug Development: Acts as a functionalized precursor for creating prodrugs with enhanced solubility, stability, or targeted release profiles.
• Anticancer Agent Research: Investigated for its potential direct or modified anticancer activity in various in vitro and in vivo models.
• Conjugate Synthesis: Utilized in the preparation of antibody-drug conjugates (ADCs) or other bioconjugates due to its reactive thiol group.
• Chemical Biology Probes: Employed in the design of molecular probes to investigate specific biological pathways and protein interactions.

Basic Information

Product Name	n-(2-Mercaptoethyl) Demecolcine
CAS No.	1217746-74-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Demecolcine 2-Mercaptoethyl Derivative; 2-((7S,12aR)-3,10-Dihydroxy-1,2,3,4,6,7,8,12a-octahydro-9-methoxy-7-methylbenzo[a]heptalen-7-yl)-2-oxoethyl 2-sulfanylethylcarbamate; N-(2-Sulfanylethyl)-2-[(7S,12aR)-3,10-dihydroxy-1,2,3,4,6,7,8,12a-octahydro-9-methoxy-7-methylbenzo[a]heptalen-7-yl]-2-oxoacetamide; Demecolcine Mercaptoethylamide; Colcemid Derivative
EINECS	Contact for details

Quality Control

Our n-(2-Mercaptoethyl) Demecolcine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) documenting purity, assay, and related substances are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) or as specified on the label or COA. Due to its sensitivity to oxidation, the container should be sealed immediately after use to minimize exposure to air.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.