Description

n-Boc-Phenyl-D5-Alaninal is a high-purity, deuterated alaninal derivative featuring a tert-butoxycarbonyl (Boc) protecting group. This compound is a critical chiral building block and advanced intermediate for the synthesis of isotopically labeled peptides and pharmaceutical compounds, enabling precise metabolic and pharmacokinetic studies. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, development of proteolysis-targeting chimeras (PROTACs), and the production of stable isotope-labeled standards for mass spectrometry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of deuterated drug candidates, particularly in oncology and metabolic disease research.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a versatile linker component in the construction of bifunctional molecules designed for targeted protein degradation.
• Isotope Labeling: Used to incorporate stable deuterium (D5) labels into peptides and small molecules for use as internal standards in Liquid Chromatography-Mass Spectrometry (LC-MS) and bioanalytical assays.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a deuterated analog to investigate isotope effects on metabolism and binding affinity.
• Peptide Synthesis: The Boc-protected alaninal is a precursor for introducing deuterated phenylalanine analogs into custom peptide sequences.
• Academic & Contract Research: Essential for chemical biology research focusing on enzyme mechanisms, protein interactions, and tracer studies.

Basic Information

Product Name	n-Boc-Phenyl-D5-Alaninal
CAS No.	1217724-86-1
Molecular Formula	C14H14D5NO3
Molecular Weight	254.34 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-3-(pentadeuterophenyl)propanal; (S)-2-((tert-Butoxycarbonyl)amino)-3-(phenyl-d5)propanal; Boc-L-Phenylalanine-d5-alaninal; tert-Butyl ((S)-1-formyl-2-(phenyl-d5)ethyl)carbamate; N-Boc-L-Phenylalanine-d5 Aldehyde; Alaninal, N-Boc-phenyl-D5-; Boc-Phe(Ph-d5)-H
EINECS	Contact for details

Quality Control

Our n-Boc-Phenyl-D5-Alaninal is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for isotopic enrichment verification, to ensure compliance with research and development standards. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D5)	≥ 98 atom % D
Optical Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.