Description

2,2-Dichloro-n-[(2S,3S)-1,1,2-Trideuterio-1,3-Dihydroxy-3-(4-Methylsulfonylphenyl)Propan-2-Yl]Acetamide is a high-purity, deuterated chemical intermediate of significant importance in advanced pharmaceutical research and development. Its core value lies in its role as a stable isotope-labeled analog, which is critical for conducting precise metabolic, pharmacokinetic, and bioanalytical studies. This compound is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the development of novel therapeutics, where understanding drug fate and interaction is paramount.

Application

• Pharmaceutical R&D: As a deuterium-labeled internal standard for the accurate quantification of parent drugs and metabolites in biological matrices using LC-MS/MS.
• Metabolic Studies: To trace and elucidate metabolic pathways and identify metabolites in preclinical and clinical studies.
• Pharmacokinetic (PK) Analysis: Enables precise measurement of drug absorption, distribution, metabolism, and excretion (ADME) parameters.
• Bioanalytical Method Development: Serves as a critical reference standard for validating sensitive and specific analytical methods in compliance with GLP guidelines.
• Drug Discovery: Used in early-stage discovery for screening and optimizing lead compounds that share the core structural scaffold.
• Isotope Dilution Mass Spectrometry: Provides high accuracy and precision in quantitative analysis by correcting for matrix effects and instrument variability.

Basic Information

Product Name	2,2-Dichloro-n-[(2S,3S)-1,1,2-Trideuterio-1,3-Dihydroxy-3-(4-Methylsulfonylphenyl)Propan-2-Yl]Acetamide
CAS No.	1217723-41-5
Molecular Formula	C12H12D3Cl2NO5S
Molecular Weight	361.25 g/mol (for most abundant isotope)
Synonyms	Deuterated 2,2-Dichloroacetamide Derivative; (2S,3S)-2-[(2,2-Dichloroacetyl)amino]-1,1,2-trideuterio-3-hydroxy-3-(4-(methylsulfonyl)phenyl)propyl Alcohol; 1,1,2-Trideuterio-1,3-Dihydroxy-3-(4-Methylsulfonylphenyl)Propan-2-Yl 2,2-Dichloroacetamide; Deuterium-labeled API Intermediate; Stable Isotope-Labeled Standard; [D3]-Labeled Acetamide Derivative; CAS 1217723-41-5
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity, essential for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D%), chemical purity, and identity confirmation. We adhere to relevant industry standards for reference materials, and custom synthesis can be performed to meet specific GMP or research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.