Description

(S)-α-(5-Bromo-2-Thiophenylmethyl)-Proline-Hcl CAS NO 1217722-51-4 is a high-purity, non-natural amino acid derivative featuring a proline backbone substituted with a brominated thiophene moiety. This compound is a critical chiral building block and intermediate in modern pharmaceutical research and development, valued for its structural complexity and defined stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for drug discovery programs targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially for neurological targets.
• Peptidomimetics Research: Used to incorporate constrained, non-proteinogenic amino acid structures into peptide analogs to enhance metabolic stability and bioavailability.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Chemical Biology: Employed in the design and synthesis of chemical probes to study enzyme function and protein-protein interactions.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in stereoselective synthetic routes.
• Reference Standard: Used as an analytical standard for quality control and method development in analytical laboratories.

Basic Information

Item	Details
Product Name	(S)-α-(5-Bromo-2-Thiophenylmethyl)-Proline Hydrochloride
CAS No.	1217722-51-4
Molecular Formula	C11H13BrClNO2S
Molecular Weight	338.65 g/mol
Synonyms	(S)-α-((5-Bromo-2-thienyl)methyl)proline hydrochloride; (S)-2-((5-Bromothiophen-2-yl)methyl)pyrrolidine-2-carboxylic acid hydrochloride; 5-Bromo-2-thiophenepropanoic acid, α-(aminocarbonyl)-, hydrochloride, (αS)-; L-Proline, α-[(5-bromo-2-thienyl)methyl]-, hydrochloride (1:1); (S)-2-((5-Bromothiophen-2-yl)methyl)proline HCl
EINECS	Contact for details

Quality Control

Our (S)-α-(5-Bromo-2-Thiophenylmethyl)-Proline-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via NMR and mass spectrometry. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.