Description

(S)-α-(4-Thiazolylmethyl)-Prohcl is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters for its role as a critical building block in the development of enantiomerically pure active pharmaceutical ingredients (APIs), where stereochemical control is paramount. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly within the fields of antiviral and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex, biologically active molecules.
• Antiviral Drug Research: Serves as a crucial precursor in the development of new antiviral compounds targeting specific viral enzymes.
• CNS-Active Compound Development: Used in research programs focused on creating new treatments for neurological disorders.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to introduce the (S)-configured stereocenter.
• Process Chemistry & Scale-Up: Utilized in route scouting and optimization for the commercial-scale production of target APIs.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control.

Basic Information

Product Name	(S)-α-(4-Thiazolylmethyl)-Prohcl
CAS No.	1217721-94-2
Molecular Formula	C8H12N2OS
Molecular Weight	184.26 g/mol
Synonyms	(S)-2-((Thiazol-4-yl)methyl)pyrrolidine; (S)-α-(4-Thiazolylmethyl)proline hydrochloride; (S)-1-(Thiazol-4-ylmethyl)proline HCl; (S)-Proline, 1-[(4-thiazolyl)methyl]-, hydrochloride (1:1); L-Proline, 1-[(4-thiazolyl)methyl]-, hydrochloride; (S)-TMP-HCl; 1217721-94-2 (free base may have different CAS)
EINECS	Contact for details

Quality Control

Our (S)-α-(4-Thiazolylmethyl)-Prohcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.