Description

Ritonavir-D6 CAS NO 1217720-20-1 is a stable isotope-labeled analog of the antiretroviral drug Ritonavir, where six hydrogen atoms are replaced by deuterium. This compound is a critical internal standard used in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical research and development laboratories, clinical testing facilities, and contract research organizations (CROs) focused on antiviral drug development and therapeutic drug monitoring.

Application

• Primary use as an Internal Standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of Ritonavir in biological matrices (plasma, serum, tissue).
• Metabolite identification and profiling studies to understand the biotransformation pathways of Ritonavir.
• Supporting Bioequivalence and Pharmacokinetic (PK/PD) studies for generic and novel formulation development.
• Use in regulated Good Laboratory Practice (GLP) and Clinical Diagnostic assays to ensure data integrity and compliance.
• Application in Drug-Drug Interaction studies investigating cytochrome P450 enzyme inhibition.
• Research into the environmental fate and analysis of pharmaceutical residues.

Basic Information

Product Name	Ritonavir-D6
CAS No.	1217720-20-1
Molecular Formula	C37H42D6N6O5S2
Molecular Weight	~ 727.0 g/mol
Synonyms	Ritonavir-d6; Norvir-d6; [D6]-Ritonavir; 5-Thiazolylmethyl [(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl-d6]carbamoyl]amino]butanoyl]amino]-1,6-diphenyl-hexan-2-yl]carbamate; L-735,524-d6; A-84538-d6
EINECS	Contact for details

Quality Control

Our Ritonavir-D6 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, suitable for the most demanding analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (D-content), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to relevant industry standards for reference materials. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.