Description

(S)-(+)-3-Hydroxytetrahydrofuran-D4 is a high-purity, isotopically labeled chiral building block, specifically the deuterated form of (S)-(+)-3-Hydroxytetrahydrofuran. This compound is critical for advanced research and development where precise molecular tracking and metabolic pathway elucidation are required. It is primarily utilized by pharmaceutical, agrochemical, and academic research institutions engaged in the synthesis of deuterated active pharmaceutical ingredients (APIs), metabolic studies, and as a standard for analytical method development.

Application

• Deuterated Active Pharmaceutical Ingredient (API) Synthesis: Serves as a key chiral intermediate in the preparation of deuterium-labeled drug candidates for improved pharmacokinetic profiles and metabolic stability studies.
• Metabolic Research & Tracer Studies: Used as a stable isotope-labeled internal standard in LC-MS and GC-MS for accurate quantification and to trace metabolic pathways in biological systems.
• Asymmetric Synthesis: Employed as a chiral synthon in the construction of complex, enantiomerically pure molecules for pharmaceuticals and fine chemicals.
• Analytical Reference Standard: Provides a certified reference material for method validation, quality control, and regulatory submissions in analytical laboratories.
• Material Science Research: Utilized in the development of novel deuterated polymers or liquid crystals where isotopic purity affects material properties.
• Agrochemical Development: Acts as a building block for creating isotopically labeled pesticides or herbicides to study environmental fate and degradation.

Basic Information

Product Name	(S)-(+)-3-Hydroxytetrahydrofuran-D4
CAS No.	1217718-57-4
Molecular Formula	C₄H₄D₄O₂
Molecular Weight	92.13 g/mol
Synonyms	(S)-(+)-3-Hydroxyoxolane-d4; (3S)-Oxolan-3-ol-d4; (S)-Tetrahydro-3-furanol-d4; (S)-3-Hydroxytetrahydrofuran-d4; (S)-3-Hydroxyoxolane-d4; (S)-Tetrahydrofuran-3-ol-d4; Deuterated (S)-3-Hydroxytetrahydrofuran; (S)-3-Hydroxytetrahydrofuran (tetradeuterated)
EINECS	Contact for details

Quality Control

Every batch of (S)-(+)-3-Hydroxytetrahydrofuran-D4 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure exceptional isotopic and chemical purity. Our quality assurance protocols are designed to meet the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing specifications for isotopic enrichment (D-atom %), chiral purity (enantiomeric excess), chemical purity, and identity is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.