Description

Cis (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-Naphthalen-1-Ol-D4 is a high-purity, deuterium-labeled stereoisomer of a tetralin derivative, serving as a critical stable isotope-labeled internal standard. Its primary value lies in enabling precise quantitative analysis and metabolic studies in complex biological matrices, ensuring data accuracy and reliability. This compound is essential for researchers and quality control laboratories in the pharmaceutical, agrochemical, and analytical chemistry sectors who require definitive reference materials for method development and validation.

Application

• Pharmaceutical Research & Development: Used as a deuterated internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of its non-labeled counterpart in pharmacokinetic, bioavailability, and bioequivalence studies.
• Metabolite Identification & Profiling: Facilitates the detection and structural elucidation of drug metabolites in in vitro and in vivo systems by providing a stable isotopic marker.
• Analytical Method Validation: Critical for developing and validating robust, regulatory-compliant (e.g., FDA, ICH guidelines) analytical methods, ensuring specificity, accuracy, and precision.
• Impurity Testing & Characterization: Aids in the identification and quantification of process-related impurities and degradation products in active pharmaceutical ingredient (API) batches.
• Environmental & Agrochemical Analysis: Employed in trace-level analysis of related chlorinated compounds in environmental samples, food, or crop protection product formulations.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as the ideal spike for IDMS, the gold-standard technique for achieving highest accuracy in quantitative measurements.

Basic Information

Product Name	Cis (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-Naphthalen-1-Ol-D4
CAS No.	1217717-42-4
Molecular Formula	C₁₆H₁₁D₄Cl₂O
Molecular Weight	298.22 g/mol (deuterated form)
Synonyms	(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenol-d4; 1,2,3,4-Tetrahydro-4-(3,4-dichlorophenyl)-1-naphthol-d4 (cis-1S,4S); Deuterated Cis-Paroxetine Intermediate; Tetralol-d4 derivative; 4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthol-d4 (cis isomer); Stable Isotope Labeled Tetralin; (1S-cis)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenol-d4
EINECS	Contact for details

Quality Control

Every batch of our Cis (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-Naphthalen-1-Ol-D4 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity to meet the exacting demands of analytical and research applications. Comprehensive testing includes identity confirmation, assay, isotopic enrichment (D-atom %), and control of related substances and residual solvents. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere or with desiccant for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.