Description

1-[2,2,3,3,5,5,6,6-Octadeuterio-4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(Imidazol-1-Ylmethyl)-1,3-Dioxolan-4-Yl]Methoxy]Phenyl]Piperazin-1-Yl]Ethanone is a deuterated analog of a key pharmaceutical intermediate, designed for advanced research and development. This compound is critical for metabolic and pharmacokinetic studies, providing enhanced analytical sensitivity and stability in tracer applications. It is primarily utilized by pharmaceutical R&D laboratories and contract research organizations (CROs) focused on drug discovery and development.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a stable isotope-labeled internal standard for the precise quantification of its non-deuterated counterpart in bioanalytical methods.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Pharmaceutical Impurity Profiling: Assists in the identification and quantification of process-related impurities and degradation products during API development.
• Mechanistic Studies: Facilitates research into metabolic pathways and enzymatic processes without interference from endogenous compounds.
• Reference Standard for Quality Control: Serves as a high-purity certified reference material for calibrating analytical instruments and validating testing protocols in GMP/GLP environments.

Basic Information

Product Name	1-[2,2,3,3,5,5,6,6-Octadeuterio-4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(Imidazol-1-Ylmethyl)-1,3-Dioxolan-4-Yl]Methoxy]Phenyl]Piperazin-1-Yl]Ethanone
CAS No.	1217706-96-1
Molecular Formula	C26H22D8Cl2N4O4
Molecular Weight	Contact for details
Synonyms	1-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(Imidazol-1-Ylmethyl)-1,3-Dioxolan-4-Yl]Methoxy]Phenyl]Piperazin-1-Yl]Ethanone-d8; Ketoconazole-d8 Impurity; Ketoconazole Deuterated Impurity; Ketoconazole-d8 Related Compound; (2R,4S)-Ketoconazole-d8 Derivative; 1-Acetyl-4-(4-((((2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine-d8; Deuterated Ketoconazole Metabolite Standard
EINECS	Contact for details

Quality Control

Every batch of this deuterated compound is produced and analyzed under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity. Our ISO-certified processes guarantee consistency for critical research applications. Comprehensive testing includes HPLC, NMR, and LC-MS to confirm identity, chemical purity, and isotopic enrichment. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (LC-MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.