Description

n-Acetyl-D3 Adamantamine is a deuterated derivative of the bioactive compound N-acetyladamantamine, where three hydrogen atoms are replaced with the stable isotope deuterium. This molecular modification is critical for enhancing metabolic stability and providing a non-radioactive isotopic tracer, making it an invaluable tool in advanced research and development. It is primarily utilized by pharmaceutical researchers and analytical chemists in the fields of drug metabolism and pharmacokinetics (DMPK), proteomics, and as an internal standard for mass spectrometry.

Application

• Deuterated Internal Standard for LC-MS/MS: Essential for the accurate quantification of N-acetyladamantamine and related metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a stable isotope-labeled tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of adamantane-based drug candidates.
• Proteomic and Metabolomic Research: Serves as a critical reagent in isotope-coded affinity tag (ICAT) and other labeling techniques for comparative protein and metabolite analysis.
• Pharmaceutical Reference Standard: Provides a certified, high-purity benchmark for method development, validation, and quality control in analytical laboratories.
• Mechanistic Biochemical Research: Aids in elucidating enzymatic pathways and reaction mechanisms where hydrogen/deuterium exchange is relevant.

Basic Information

Product Name	n-Acetyl-D3 Adamantamine
CAS No.	1217704-63-6
Molecular Formula	C12H16D3NO
Molecular Weight	195.30 g/mol
Synonyms	N-Acetyl-1-adamantylamine-d3; 1-(Acetylamino)adamantane-d3; N-(1-Adamantyl)acetamide-d3; Deuterated N-Acetyladamantamine; N-Acetyladamantan-1-amine-d3; Adamantane-1-acetamide-d3; Acetamide, N-(1-adamantyl)-, d3-
EINECS	Contact for details

Quality Control

Our n-Acetyl-D3 Adamantamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H & ¹³C) for structural confirmation and deuterium incorporation, and HPLC for purity assessment, to ensure it meets the high standards required for research and analytical applications. A detailed Certificate of Analysis (COA) specifying isotopic purity, chemical purity, and residual solvent levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation from moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.