Description

Carbonic Acid 2,5-Dioxopyrrolidin-1-Yl (S)-Tetrahydrofuran-D4-3-Yl Ester is a specialized deuterated active ester reagent used in advanced synthetic chemistry. This compound is critical for introducing stable isotope labels into target molecules, enabling precise analytical and pharmacokinetic studies. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and analytical reference standard industries for applications requiring high isotopic purity and chemical specificity.

Application

• Deuterium Labeling Reagent: For the site-specific incorporation of deuterium (D) atoms into active pharmaceutical ingredients (APIs) and other organic molecules.
• Pharmaceutical Research: Synthesis of stable isotope-labeled internal standards for use in Liquid Chromatography-Mass Spectrometry (LC-MS) and bioanalytical method development.
• Metabolic Studies: Preparation of deuterated probes to study drug metabolism and pharmacokinetics (DMPK) in preclinical research.
• Mechanistic Chemistry: Employed as a tool in reaction mechanism elucidation and kinetic isotope effect (KIE) studies.
• Agrochemical Development: Used in the synthesis of labeled agrochemicals for environmental fate and residue analysis.
• NMR Spectroscopy: Serves as a precursor for preparing deuterated compounds to simplify complex nuclear magnetic resonance (NMR) spectra.

Basic Information

Product Name	Carbonic Acid 2,5-Dioxopyrrolidin-1-Yl (S)-Tetrahydrofuran-D4-3-Yl Ester
CAS No.	1217695-90-3
Molecular Formula	C9H7D4NO5
Molecular Weight	217.20 g/mol
Synonyms	(S)-Tetrahydrofuran-3-yl (2,5-dioxopyrrolidin-1-yl) carbonate-d4; 1-[(Tetrahydro-2-furanyl)methyl] 2,5-Pyrrolidinedione Carbonate-d4; N-Succinimidyl (S)-Tetrahydrofuran-3-yl Carbonate-d4; Deuterated N-Succinimidyl (S)-THF-3-yl Carbonate; (S)-3-(N-Succinimidyloxycarbonyloxy)tetrahydrofuran-d4; NSC-D4 Active Ester; (S)-THF-3-yl N-succinimidyl carbonate-d4
EINECS	Contact for details

Quality Control

Every batch of Carbonic Acid 2,5-Dioxopyrrolidin-1-Yl (S)-Tetrahydrofuran-D4-3-Yl Ester is manufactured and tested under strict quality management systems. We ensure high chemical and isotopic purity through advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opened to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.