Description

(3S)-n-Methyl-3-(2,3,4,5,6-Pentadeuteriophenyl)-3-[4-(Trifluoromethyl)Phenoxy]Propan-1-Amine:Hydrochloride is a high-purity, deuterium-labeled chemical reference standard crucial for advanced analytical research. This compound matters for its role in enabling precise quantification and metabolic pathway tracing in complex biological matrices. Pharmaceutical R&D laboratories and contract research organizations (CROs) specializing in drug metabolism and pharmacokinetics (DMPK) studies are the primary users of this material.

Application

• Internal Standard for LC-MS/MS: Used as a stable, isotopically labeled internal standard for the accurate quantification of its non-deuterated counterpart in bioanalytical methods.
• Drug Metabolism Studies (DMPK): Essential for tracing metabolic pathways, identifying metabolites, and studying the pharmacokinetic profile of pharmaceutical candidates.
• Biomedical Research: Supports proteomics and biomarker discovery research where precise measurement of specific analytes is required.
• Method Development & Validation: Serves as a critical component in developing and validating robust, regulatory-compliant analytical methods for clinical and non-clinical trials.
• Quality Control in API Manufacturing: Employed in the quality control laboratories of active pharmaceutical ingredient (API) manufacturers to ensure product purity and consistency.

Basic Information

Item	Detail
Product Name	(3S)-n-Methyl-3-(2,3,4,5,6-Pentadeuteriophenyl)-3-[4-(Trifluoromethyl)Phenoxy]Propan-1-Amine:Hydrochloride
CAS No.	1217680-98-2
Molecular Formula	C18H14D5ClF3NO
Molecular Weight	Contact for details
Synonyms	1-Propanamine, 3-(2,3,4,5,6-pentadeuteriophenyl)-N-methyl-3-[4-(trifluoromethyl)phenoxy]-, hydrochloride, (3S)-; (3S)-N-Methyl-3-(2,3,4,5,6-pentadeuteriophenyl)-3-[4-(trifluoromethyl)phenoxy]propan-1-amine hydrochloride; Deuterated (S)-Fluoxetine Metabolite Standard; d5-Norfluoxetine Hydrochloride (S-isomer); Isotopically Labeled Norfluoxetine-d5 HCl; Pharmaceutical Reference Standard d5-Norfluoxetine HCl
EINECS	Contact for details

Quality Control

Every batch of our (3S)-n-Methyl-3-(2,3,4,5,6-Pentadeuteriophenyl)-3-[4-(Trifluoromethyl)Phenoxy]Propan-1-Amine:Hydrochloride is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and isotopic enrichment meet the exacting standards required for analytical research. A detailed Certificate of Analysis (COA) including results from HPLC, NMR, and MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity (Titration)	Contact for details
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.