Description

Des-n-(Methoxycarbonyl)-L-tert-Leucine Bis-Boc Atazanavir-D5 is a high-purity, isotopically labeled advanced pharmaceutical intermediate (API intermediate) and a key building block in the synthesis of deuterated drug candidates. This compound is critical for research and development in medicinal chemistry, particularly for creating stable isotope-labeled analogs of the HIV protease inhibitor Atazanavir. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers specializing in the development of deuterated pharmaceuticals and high-value active pharmaceutical ingredients (APIs).

Application

• Deuterated Drug Synthesis: A crucial precursor for the preparation of deuterium-labeled Atazanavir, used in drug metabolism and pharmacokinetics (DMPK) studies.
• Pharmaceutical R&D: Serves as a key intermediate in the research and development of novel protease inhibitors and deuterated chemical entities.
• Metabolite Standard Production: Used to synthesize isotopically labeled internal standards for accurate LC-MS/MS analysis in bioanalytical laboratories.
• Mechanistic Studies: Enables tracing and mechanistic investigation of metabolic pathways for the parent drug Atazanavir.
• Process Chemistry: Employed in route scouting and optimization for the scalable synthesis of deuterated APIs.
• Reference Standard: Can be used as a certified reference material (CRM) for quality control of deuterated pharmaceutical products.

Basic Information

Product Name	Des-n-(Methoxycarbonyl)-L-tert-Leucine Bis-Boc Atazanavir-D5
CAS No.	1217665-60-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Bis-Boc Atazanavir-D5 Intermediate; (3S,8S,9S,12S)-9-Benzyl-3,12-di-tert-butyl-8-[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl]-1,4,7,10-tetrakis(tert-butoxycarbonyl)-13,13-dideuterio-6,11-dioxo-1,4,7,10-tetrazatridecan-5-one; Deuterated Atazanavir Bis-Boc Intermediate; L-tert-Leucine Atazanavir-D5 Derivative; Atazanavir Deuterated Precursor; N-Protected Atazanavir-D5 Intermediate
EINECS	Contact for details

Quality Control

Our Des-n-(Methoxycarbonyl)-L-tert-Leucine Bis-Boc Atazanavir-D5 is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment, suitable for sensitive pharmaceutical research. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic purity (D-content), and identification data. We adhere to cGMP guidelines for the production of advanced pharmaceutical intermediates, ensuring traceability and consistency for critical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 95 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.