Description

Tilidine-D6 Hydrochloride is a deuterated internal standard of the opioid analgesic Tilidine, specifically designed for high-precision analytical applications. This stable isotope-labeled compound is essential for ensuring accurate quantification and method validation in complex biological matrices. It is primarily utilized by pharmaceutical R&D laboratories, forensic toxicology units, and clinical research organizations engaged in pharmacokinetic studies and drug metabolism research.

Application

• Internal Standard for LC-MS/MS and GC-MS: Critical for the accurate quantification of Tilidine and its metabolites in bioanalytical methods.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetics (DMPK) studies for precise tracer analysis.
• Forensic Toxicology: Enables reliable identification and measurement of Tilidine in forensic casework and compliance testing.
• Clinical Trial Analysis: Supports the bioanalysis of patient samples during clinical studies for new analgesic formulations.
• Reference Material for Method Development: Serves as a key calibrant in developing and validating robust analytical protocols.
• Quality Control in Manufacturing: Can be employed in impurity profiling and stability testing of pharmaceutical products.

Basic Information

Product Name	Tilidine-D6 Hydrochloride
CAS No.	1217655-15-6
Molecular Formula	C17H19D6NO2·HCl
Molecular Weight	Approx. 329.90 g/mol
Synonyms	Ethyl (1R,2R)-2-[(dimethylamino)methyl]-1-phenyl-3-cyclohexene-1-carboxylate-D6 hydrochloride; Tilidine-d6 HCl; Tilidine (hexadeuterated) hydrochloride; (±)-Tilidine-D6 hydrochloride; Tilidine Internal Standard; 1-Phenyl-1-(2-dimethylaminomethylcyclohex-1-en-3-yl)propionate-D6 hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Tilidine-D6 Hydrochloride is manufactured under controlled conditions and subjected to rigorous analytical testing to ensure the highest isotopic purity and chemical integrity. Our quality assurance protocol includes comprehensive characterization by NMR, MS, and HPLC to confirm identity, purity, and isotopic enrichment. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.