Description

Brinzolamide-D5 CAS NO 1217651-02-9 is a deuterated analog of the carbonic anhydrase inhibitor Brinzolamide, where five hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is a critical reference standard and internal standard in quantitative analytical methods, ensuring accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in the development and quality control of ophthalmic medications.

Application

• Primary use as a stable isotope-labeled internal standard for the precise quantification of Brinzolamide in biological matrices (e.g., plasma, serum) using LC-MS/MS and GC-MS.
• Essential reference material for method development, validation, and quality control in pharmaceutical analysis.
• Facilitates drug metabolism and pharmacokinetics (DMPK) studies, including absorption, distribution, metabolism, and excretion (ADME) profiling.
• Used in bioanalytical research to support clinical trials and regulatory submissions for generic and novel drug formulations.
• Critical for ensuring data integrity and compliance with Good Laboratory Practice (GLP) and other regulatory guidelines in analytical testing.
• Supports impurity profiling and characterization studies in active pharmaceutical ingredient (API) manufacturing.

Basic Information

Item	Detail
Product Name	Brinzolamide-D5
CAS No.	1217651-02-9
Molecular Formula	C12H16D5N3O5S3
Molecular Weight	388.53 g/mol (approx.)
Synonyms	Brinzolamide-d5; (4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide-d5; Azopt-d5; AL-4862-d5; Brinzolamide (ethyl-d5); Deuterated Brinzolamide; Brinzolamide Internal Standard; Stable Isotope Labeled Brinzolamide
EINECS	Contact for details

Quality Control

Every batch of Brinzolamide-D5 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to confirm identity, purity, and isotopic enrichment, ensuring it meets the exacting requirements for use as a certified reference material. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting results for assay, isotopic purity, and related substances by HPLC and/or LC-MS. Our quality commitment aligns with standards relevant to high-purity analytical and pharmaceutical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.