Description

Zolmitriptan-D6 CAS NO 1217644-84-2 is a deuterium-labeled analog of Zolmitriptan, a potent and selective serotonin (5-HT1B/1D) receptor agonist. This stable isotope-labeled compound is an essential reference standard and internal standard for quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities involved in the development and quality control of triptan-based migraine therapeutics.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard for the precise quantification of Zolmitriptan and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic & Metabolism Research: Enables accurate tracing of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Bioanalytical Method Development & Validation: Used to develop, optimize, and validate robust, high-sensitivity analytical methods in compliance with FDA, EMA, and ICH guidelines.
• Drug Impurity Profiling & Characterization: Aids in the identification and quantification of process-related impurities and degradation products during drug substance and product development.
• Forensic & Doping Control Analysis: Provides a definitive reference for confirmatory testing in forensic toxicology and anti-doping programs.
• Stable Isotope Dilution Assays (SIDA): Fundamental component for achieving high precision and accuracy in quantitative mass spectrometry-based assays.

Basic Information

Item	Details
Product Name	Zolmitriptan-D6
CAS No.	1217644-84-2
Molecular Formula	C16H15D6N3O2
Molecular Weight	291.38 g/mol
Synonyms	Zolmitriptan-d6; (S)-4-[[3-[2-(Dimethylamino-d6)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone; 4-[[3-[2-(Dimethylamino-d6)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone; Zomig-d6; Stable Isotope Labeled Zolmitriptan; Deuterated Zolmitriptan Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Zolmitriptan-D6 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, confirmed by advanced techniques including NMR (1H, 13C), high-resolution mass spectrometry (HRMS), and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and conformity to customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.