Description

(-)-2-Amino-6-Propionamido-D3-Tetrahydrobenzothiazole CAS NO 1217644-20-6 is a high-purity, deuterated chiral intermediate of significant interest in advanced pharmaceutical research and development. Its core value lies in its utility as a building block for creating isotopically labeled compounds, which are essential for pharmacokinetic, metabolic, and bioanalytical studies. This product is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and contract research sectors.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Deuterated Compound Synthesis: Serves as a precursor for creating deuterium-labeled active pharmaceutical ingredients (APIs) to enhance metabolic stability and study drug pathways.
• Metabolic Tracer Development: Used in the preparation of internal standards for Liquid Chromatography-Mass Spectrometry (LC-MS) to ensure accurate quantification in bioanalytical assays.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a defined stereochemical and isotopic scaffold for analog generation.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development of labeled compounds for client projects.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and isotope chemistry.

Basic Information

Product Name	(-)-2-Amino-6-Propionamido-D3-Tetrahydrobenzothiazole
CAS No.	1217644-20-6
Molecular Formula	C₁₀H₁₃D₃N₃OS
Molecular Weight	~227.31 g/mol
Synonyms	(6S)-2-Amino-6-[(2,2,2-trideuteriopropanoyl)amino]-4,5,6,7-tetrahydro-1,3-benzothiazole; (-)-2-Amino-6-propionamido-D3-4,5,6,7-tetrahydrobenzothiazole; 2-Amino-6-propionamido-D3-tetrahydrobenzothiazole; Deuterated Pramipexole Intermediate; (S)-2-Amino-6-(propionamido-D3)-4,5,6,7-tetrahydrobenzothiazole; 6S-Tetrahydrobenzothiazole-D3 derivative; 1217644-20-6
EINECS	Contact for details

Quality Control

Our (-)-2-Amino-6-Propionamido-D3-Tetrahydrobenzothiazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity and isotopic enrichment verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, assay, and identity are provided and available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.