Description

(1S,2R)-2-Amino-2,3,3-Trideuterio-3-Fluoro-1-(4-Methylsulfonylphenyl)Propan-1-Ol is a high-purity, deuterated and fluorinated chiral amino alcohol building block of significant interest in advanced pharmaceutical research. Its unique structure, featuring a deuterium-labeled amino group and a fluorine atom, makes it a critical intermediate for the development of novel drug candidates, particularly in creating compounds with improved metabolic stability and pharmacokinetic profiles. This compound is essential for medicinal chemists and process development scientists working in pharmaceutical R&D, specifically for applications in deuterium labeling strategies and the synthesis of bioactive molecules targeting neurological and inflammatory pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of deuterated active pharmaceutical ingredients (APIs) and drug candidates.
• Deuterium Labeling Agent: Used in the preparation of isotopically labeled compounds for drug metabolism and pharmacokinetics (DMPK) studies, enhancing metabolic stability.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) exploration in neuroscience and immunology targets.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for complex chiral molecules.
• Reference Standard: Used as an analytical standard for quality control and method validation in pharmaceutical manufacturing.
• Biochemical Tool Compound: Potential use in probing enzyme mechanisms and biological pathways due to its fluorine and deuterium atoms.

Basic Information

Product Name	(1S,2R)-2-Amino-2,3,3-Trideuterio-3-Fluoro-1-(4-Methylsulfonylphenyl)Propan-1-Ol
CAS No.	1217625-88-1
Molecular Formula	C10H11D3FNO3S
Molecular Weight	250.29 g/mol
Synonyms	(1S,2R)-2-Amino-2,3,3-trideuterio-3-fluoro-1-(4-(methylsulfonyl)phenyl)propan-1-ol; 2-Amino-2,3,3-trideuterio-3-fluoro-1-(4-methylsulfonylphenyl)propan-1-ol, (1S,2R)-; (1S,2R)-2-Amino-2,3,3-trideuterio-3-fluoro-1-(p-tolylsulfonyl)propan-1-ol; Fluorodeuterated Amino Alcohol Derivative; 1217625-88-1; (1S,2R)-rel-2-Amino-2,3,3-trideuterio-3-fluoro-1-[4-(methylsulfonyl)phenyl]-1-propanol
EINECS	Contact for details

Quality Control

Our (1S,2R)-2-Amino-2,3,3-Trideuterio-3-Fluoro-1-(4-Methylsulfonylphenyl)Propan-1-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, isotopic enrichment verification, and impurity profiling by advanced techniques like HPLC, GC, and NMR to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Deuterium Enrichment (MS/NMR)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.