Description

Halofuginone Hydrochloride is a synthetic quinazolinone derivative with potent biological activity. This compound is valued for its specific inhibitory effects on collagen synthesis and certain parasitic and viral pathways. It serves as a critical active pharmaceutical ingredient (API) and research chemical for developers in the pharmaceutical, veterinary medicine, and life science research sectors.

Application

• Pharmaceutical API: Used in the development of antifibrotic therapies targeting conditions like scleroderma and liver fibrosis.
• Veterinary Anticoccidial Agent: A key component in poultry and livestock feed additives for the prevention of coccidiosis.
• Biochemical Research: Employed as a selective inhibitor of prolyl-tRNA synthetase to study collagen production, T-cell differentiation, and aminoacylation.
• Antiviral Research: Investigated for its potential activity against specific viruses, including certain coronaviruses, due to its mechanism of action.
• Oncology Research: Studied for its anti-angiogenic and anti-metastatic properties in various cancer models.
• Dermatology R&D: Explored in topical formulations for treating keloids, hypertrophic scars, and other fibrotic skin disorders.

Basic Information

Product Name	Halofuginone Hydrochloride
CAS No.	1217623-74-9
Molecular Formula	C16H17BrClN3O3 • HCl
Molecular Weight	495.6 g/mol
Synonyms	Halofuginone HBr; Halofuginone Hydrobromide; 7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone Hydrochloride; RU-19110 Hydrochloride; NSC-713105; Stenorol (Veterinary Brand); Tempostatin (Research Use)
EINECS	Contact for details

Quality Control

Our Halofuginone Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and MS to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments. Production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.