Description

[2H3]-Stavudine is a deuterium-labeled analog of the nucleoside reverse transcriptase inhibitor stavudine (d4T), designed for use as an internal standard in quantitative mass spectrometry. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of analytical methods in pharmacokinetic and metabolic studies. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require precise quantification of stavudine in complex biological matrices.

Application

• Mass Spectrometry Internal Standard: Primary use as a deuterated internal standard for the accurate quantification of stavudine via LC-MS/MS and GC-MS methods.
• Pharmacokinetic Research: Enables precise measurement of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Bioanalytical Method Development & Validation: Serves as a critical reference material for developing, validating, and complying with regulatory guidelines (e.g., FDA, EMA) for bioanalytical assays.
• Drug Metabolism Studies: Used to track and quantify parent drug and potential metabolites in in vitro and in vivo metabolism experiments.
• Quality Control & Assurance: Supports analytical QC in pharmaceutical manufacturing to ensure batch consistency and purity of the active pharmaceutical ingredient (API).
• Forensic & Doping Analysis: Applied in specialized testing laboratories for the definitive identification and quantification of stavudine.

Basic Information

Product Name	[2H3]-Stavudine
CAS No.	1217619-42-5
Molecular Formula	C10H9D3N2O4
Molecular Weight	227.23 g/mol (for C10H9D3N2O4)
Synonyms	Stavudine-d3; d4T-d3; 1-((2R,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methyl-2,4(1H,3H)-pyrimidinedione-d3; 2',3'-Didehydro-3'-deoxythymidine-d3; 3'-Deoxy-2',3'-didehydrothymidine-d3; Zerit-d3 (labeled); BMS-236216-13 (labeled)
EINECS	Contact for details

Quality Control

Our [2H3]-Stavudine is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic purity (by MS), and residual solvent content. We adhere to relevant industry standards for reference materials, and custom synthesis to meet specific purity or enrichment specifications is available.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storage under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99.0 atom % D
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.