Description

2,2-Dichloro-n-[(2R,3S)-1,1,2-Trideuterio-1-Fluoro-3-Hydroxy-3-(4-Methylsulfonylphenyl)Propan-2-Yl]Acetamide is a high-purity, deuterated and fluorinated chiral intermediate of significant importance in advanced pharmaceutical research and development. Its complex, stereospecific structure makes it a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular targeting. This compound is essential for medicinal chemists and process development scientists working on next-generation drugs, especially in oncology and metabolic disease research, where isotopic labeling and fluorine substitution are key strategies for optimizing pharmacokinetics and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel, deuterium-labeled and fluorinated active pharmaceutical ingredients (APIs).
• Isotope-Labeled Compound Synthesis: Serves as a deuterium (D)-labeled precursor for metabolic studies, tracer applications, and the development of drugs with improved metabolic profiles.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the impact of fluorine and deuterium substitution on drug potency, selectivity, and ADME properties.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for complex, stereochemically defined molecules.
• Reference Standard: Can be utilized as an analytical standard for quality control and regulatory submissions in pharmaceutical manufacturing.

Basic Information

Product Name	2,2-Dichloro-n-[(2R,3S)-1,1,2-Trideuterio-1-Fluoro-3-Hydroxy-3-(4-Methylsulfonylphenyl)Propan-2-Yl]Acetamide
CAS No.	1217619-10-7
Molecular Formula	C12H11D3Cl2FNO4S
Molecular Weight	369.24 g/mol
Synonyms	2,2-Dichloro-N-[(2R,3S)-1,1,2-trideuterio-1-fluoro-3-hydroxy-3-(4-(methylsulfonyl)phenyl)propan-2-yl]acetamide; (2R,3S)-2-Acetamido-1,1,2-trideuterio-3-fluoro-3-(4-methylsulfonylphenyl)propyl-2,2-dichloroacetate (related ester); Deuterated Fluorophenylsulfonyl Propanamide Intermediate; CAS 1217619-10-7; D3-Fluorinated Chiral Acetamide Derivative
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality control protocols suitable for research and pharmaceutical development. Each batch is characterized using advanced analytical techniques including HPLC, NMR (¹H, ¹³C, ¹⁹F), and Mass Spectrometry to confirm identity, chiral purity, isotopic enrichment, and chemical purity. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment. Our quality system is designed to support regulatory filings, and we can supply material produced under GMP-like conditions for advanced development stages upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere at lower temperatures (e.g., -20°C) to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Deuterium Incorporation (MS)	≥ 95 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.