Description

cis-Atovaquone-D5 (Contains 10% Trans Isomer) is a deuterated isotopologue of the antimalarial and antipneumocystis agent atovaquone, specifically labeled with five deuterium atoms. This compound serves as a critical internal standard for the precise quantification and pharmacokinetic studies of atovaquone in biological matrices using mass spectrometry. It is an essential analytical tool for pharmaceutical R&D and quality control laboratories focused on developing and monitoring antimalarial and antiprotozoal therapies.

Application

• Internal Standard for Bioanalysis: Primary use as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS methods for accurate quantification of atovaquone in plasma, serum, and other biological samples.
• Pharmacokinetic and Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Pharmaceutical Quality Control: Used in assay development and validation to ensure the potency and purity of atovaquone in active pharmaceutical ingredients (APIs) and finished drug products.
• Reference Material for Method Development: Serves as a certified reference material for calibrating analytical instruments and developing regulatory-compliant testing protocols.
• Doping Control Analysis: Potential application in sports anti-doping laboratories for method development related to prohibited substances.

Basic Information

Product Name	cis-Atovaquone-D5 (Contains 10% Trans Isomer)
CAS No.	1217612-80-0
Molecular Formula	C22H14D5ClO3
Molecular Weight	369.86 g/mol (deuterated form)
Synonyms	2-[trans-4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione-d5; Atovaquone-d5; Atovaquone (phenyl-d5); 566C80-d5; Mepron-d5; trans-Atovaquone-d5 (major component); (+/-)-trans-2-(4-(4-Chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone-d5; BW 566C80-d5
EINECS	Contact for details

Quality Control

Our cis-Atovaquone-D5 is manufactured under strict quality systems to ensure high chemical and isotopic purity suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (by HPLC), isotopic enrichment, chemical purity, and the specified isomeric ratio. We adhere to relevant industry standards for reference materials and can provide support for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥98.0% (cis-Atovaquone-D5 + trans isomer)
Isomeric Composition (cis:trans)	~90:10
Isotopic Purity (D5)	≥98 atom % D
Chemical Purity (HPLC)	≥95.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.