Description

(S)-1-Phenyl-1,2,3,4-Tetrahydroisoquinoline-D5 is a high-purity, deuterium-labeled isotopologue of a key chiral tetrahydroisoquinoline scaffold. This compound matters as a critical internal standard and tracer in quantitative analytical methods, ensuring accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily needed by pharmaceutical R&D laboratories and CROs engaged in the development and analysis of active pharmaceutical ingredients (APIs) and metabolites that utilize the 1-phenyl-1,2,3,4-tetrahydroisoquinoline structure.

Application

• Internal Standard for LC-MS/MS: Essential for precise quantification in bioanalytical assays due to its nearly identical chemical properties and distinct mass shift.
• Metabolic Pathway Tracing: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug molecules in biological systems.
• Pharmaceutical Reference Standard: Serves as a certified reference material for method development, validation, and quality control in API manufacturing.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy analytical techniques to minimize matrix effects and improve data precision.
• Neurological Research: Acts as a tool compound in neuroscience for studying receptors and enzymes where the tetrahydroisoquinoline moiety is pharmacologically relevant.
• Chemical Synthesis Intermediate: Used in the synthesis of deuterium-labeled analogs of more complex molecules for research purposes.

Basic Information

Product Name	(S)-1-Phenyl-1,2,3,4-Tetrahydroisoquinoline-D5
CAS No.	1217607-42-5
Molecular Formula	C15H10D5N
Molecular Weight	212.33 g/mol
Synonyms	(S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline-2,3,4,6,7-D5; (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline-d5; (S)-PTIQ-D5; (S)-1-Phenyl-3,4-dihydroisoquinoline-D5; (S)-1-Phenyl-3,4-dihydro-2(1H)-isoquinolone-D5 (incorrect but common search); Deuterated (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline; (S)-1-Phenyl-1,2,3,4-THIQ-D5
EINECS	Contact for details

Quality Control

Our (S)-1-Phenyl-1,2,3,4-Tetrahydroisoquinoline-D5 is manufactured under strict quality systems to ensure the high isotopic purity and chemical integrity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, chemical purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity (GC)	≥ 97.0%
Optical Purity (Chiral HPLC)	≥ 99.0% ee
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.