Description

n-Boc-4-[Bis(2-Hydroxyethyl-D4)Amino]-L-Phenylalanine Methyl Ester CAS NO 1217602-23-7 is a deuterated, protected amino acid derivative of significant value in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of isotopically labeled peptides and active pharmaceutical ingredients (APIs), enabling sophisticated metabolic and pharmacokinetic studies. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug discovery, proteomics, and the development of novel therapeutic agents.

Application

• Deuterated API Synthesis: A key intermediate for incorporating stable deuterium isotopes into peptide-based and small molecule pharmaceuticals to alter metabolic profiles.
• Metabolic Tracer Development: Used in the creation of internal standards and tracers for mass spectrometry-based assays in drug metabolism and pharmacokinetics (DMPK) studies.
• Peptide Chemistry: Serves as a protected, deuterium-labeled phenylalanine derivative in solid-phase and solution-phase peptide synthesis for research purposes.
• Proteomics Research: Employed in the synthesis of isotopically labeled peptides for use as quantitative standards in proteomic analysis.
• Medicinal Chemistry: Provides a versatile scaffold for structure-activity relationship (SAR) studies and the development of novel drug candidates with improved properties.
• Bioconjugation: The protected amine and hydroxyl groups offer handles for further chemical modification and linker attachment in bioconjugate chemistry.

Basic Information

Product Name	n-Boc-4-[Bis(2-Hydroxyethyl-D4)Amino]-L-Phenylalanine Methyl Ester
CAS No.	1217602-23-7
Molecular Formula	C19H25D4N2O6
Molecular Weight	~385.47 g/mol
Synonyms	Boc-4-[Bis(2-hydroxyethyl-d4)amino]-L-Phe-OMe; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-[4-[bis(2-hydroxyethyl-d4)amino]phenyl]propanoic acid methyl ester; Methyl N-Boc-4-[bis(2-hydroxyethyl-d4)amino]-L-phenylalaninate; Deuterated Boc-Phe(4-NEt2OH-d4)-OMe; L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-[bis(2-hydroxyethyl-d4)amino]-, methyl ester; 1217602-23-7; Boc-Phe(4-N(CD2CD2OD)2)-OMe
EINECS	Contact for details

Quality Control

Our n-Boc-4-[Bis(2-Hydroxyethyl-D4)Amino]-L-Phenylalanine Methyl Ester is manufactured under controlled conditions to ensure high chemical purity and isotopic enrichment. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C) for structural confirmation and deuterium incorporation, HPLC for chemical purity, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Deuterium Enrichment (MS)	≥ 98 atom % D
Optical Rotation	Specific rotation provided on COA
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.