Description

(2S)-N-(2-Boc-Amino-3-Phenyl-D5-Propyl) Boc-Glycine CAS NO 1217601-60-9 is a high-purity, deuterium-labeled Boc-protected dipeptide building block. This compound is critical for advanced pharmaceutical research, particularly in the development of peptide-based drugs and metabolic studies, where its isotopic labeling provides essential analytical advantages. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, proteomics, and the synthesis of novel therapeutic agents requiring stable isotope incorporation.

Application

• Pharmaceutical Intermediate: A key building block in the solid-phase and solution-phase synthesis of complex, deuterium-labeled peptides for drug discovery and development.
• Metabolic Research: Used as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for accurate quantification and metabolic pathway tracing.
• Proteomics & Biomarker Studies: Enables the synthesis of isotopically coded peptides for use in quantitative proteomics and the search for disease biomarkers.
• Medicinal Chemistry: Facilitates structure-activity relationship (SAR) studies by allowing the precise incorporation of deuterium at specific sites to investigate pharmacokinetic properties like metabolic stability.
• Academic Research: Serves as a specialized reagent in university and institutional labs for studying peptide chemistry, isotope effects, and advanced organic synthesis methodologies.

Basic Information

Product Name	(2S)-N-(2-Boc-Amino-3-Phenyl-D5-Propyl) Boc-Glycine
CAS No.	1217601-60-9
Molecular Formula	C₂₁H₂₆D₅N₃O₆
Molecular Weight	424.53 g/mol
Synonyms	Boc-Gly-(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(phenyl-d5)propylamide; N-[(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(pentadeuteriophenyl)propyl]-2-[(tert-butoxycarbonyl)amino]acetamide; Boc-Gly-L-Phe(D5)-NH-Boc; Deuterated Boc-Protected Dipeptide; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(phenyl-d5)-N-[(tert-butoxycarbonyl)glycyl]propanamide
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as purity (by HPLC), isotopic purity (D-content), and identification (by NMR and MS). Our quality system is designed to meet the exacting standards required for research and pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic nature, the container should be sealed under an inert atmosphere after opening to maintain stability and prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.