Description

1H-Indene-1-Pentanol, 4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]octahydro-α,α,ε,7a-tetramethyl-, (εs,1R,3aR,4S,7aR)- is a high-purity, advanced pharmaceutical intermediate characterized by its complex, stereochemically defined structure. This compound is critical for enabling precise synthetic pathways in the development of novel active pharmaceutical ingredients (APIs), particularly in the synthesis of complex terpenoid-based molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of high-value therapeutic agents, where its specific stereochemistry is essential for biological activity and process consistency.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of complex, biologically active compounds, including potential anti-inflammatory or antiviral agents.
• Organic Synthesis Research: Used in academic and industrial R&D laboratories for exploring new synthetic methodologies and constructing intricate molecular architectures.
• Process Chemistry Development: Serves as a critical intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Stereoselective Synthesis: Employed in reactions requiring high enantiomeric or diastereomeric purity due to its defined stereocenters, which can influence the stereochemical outcome of subsequent transformations.
• Fine Chemical Production: A valuable precursor in the manufacture of specialty chemicals where the indene and silyl-protected alcohol functionalities are required.

Basic Information

Product Name	1H-Indene-1-Pentanol, 4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]octahydro-α,α,ε,7a-tetramethyl-, (εs,1R,3aR,4S,7aR)-
CAS No.	1217549-29-5
Molecular Formula	C22H44O2Si
Molecular Weight	368.68 g/mol
Synonyms	(1R,3aR,4S,7aR)-4-[(tert-Butyldimethylsilyl)oxy]octahydro-α,α,ε,7a-tetramethyl-1H-indene-1-pentanol; (1R,3aR,4S,7aR)-4-[(Tert-Butyldimethylsilyl)oxy]-α,α,ε,7a-tetramethyloctahydro-1H-indene-1-pentanol; 4-[(tert-Butyldimethylsilyl)oxy]-α,α,ε,7a-tetramethyloctahydro-1H-indene-1-pentanol; TBS-protected indene-pentanol derivative; tert-Butyldimethylsilyl ether of indene pentanol
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC, GC, NMR, and chiral analysis, to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support development and commercial projects requiring compliance with cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep away from oxidizing agents. Due to its sensitivity, the container should be allowed to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.