Description

10,11-Dihydro-10,11-Dihydroxy Carbamazepine is a key pharmacologically active metabolite of the anticonvulsant drug carbamazepine. This compound matters for its critical role in pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in bioequivalence studies, therapeutic drug monitoring, and the synthesis of novel pharmaceutical agents.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of carbamazepine and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Used in research to understand the metabolic pathways, bioavailability, and elimination profile of carbamazepine.
• Analytical Method Development: Essential for developing and validating high-performance liquid chromatography (HPLC), LC-MS/MS, and other chromatographic methods in clinical and forensic toxicology.
• Impurity Profiling: Employed as an impurity standard to monitor and control the quality of carbamazepine active pharmaceutical ingredient (API) during manufacturing.
• Biomedical Research: Utilized in preclinical and clinical studies to investigate the efficacy, safety, and side-effect profiles associated with carbamazepine therapy.

Basic Information

Product Name	10,11-Dihydro-10,11-Dihydroxy Carbamazepine
CAS No.	1217528-81-8
Molecular Formula	C15H14N2O3
Molecular Weight	270.28 g/mol
Synonyms	10,11-Dihydro-10,11-dihydroxycarbamazepine; CBZ-diol; Carbamazepine-10,11-dihydrodiol; 10,11-Dihydroxy-10,11-dihydrocarbamazepine; trans-10,11-Dihydro-10,11-dihydroxy Carbamazepine; Carbamazepine Dihydrodiol; 5H-Dibenz[b,f]azepine-10,11(5H,11aH)-diol, 5-carbamoyl-; 10,11-Dihydroxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
EINECS	Contact for details

Quality Control

Our 10,11-Dihydro-10,11-Dihydroxy Carbamazepine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. The compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.