Description

Sodium:(2S,4S)-4-Cyclohexyl-1-[2-[Hydroxy-[4-(2,3,4,5,6-Pentadeuteriophenyl)Butyl]Phosphoryl]Acetyl]Pyrrolidine-2-Carboxylate CAS NO 1217522-63-8 is a high-purity, deuterium-labeled sodium salt of a complex pyrrolidine carboxylate derivative. This compound is of critical importance as a stable isotope-labeled internal standard for quantitative mass spectrometry analysis, ensuring unparalleled accuracy and reliability in bioanalytical measurements. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced pharmacokinetic, metabolomic, and proteomic studies.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the precise quantification of its non-deuterated counterpart or related analytes in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmaceutical Metabolism Studies (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) by correcting for matrix effects and instrument variability in mass spectrometry.
• Biomarker Discovery and Validation: Used in targeted metabolomics and proteomics workflows to achieve high-fidelity quantification of low-abundance biomarkers in disease research.
• Bioanalytical Method Development: Essential for developing, validating, and transferring robust, GLP-compliant analytical methods in regulatory submissions for new drug entities.
• Clinical Research Assays: Supports the development of high-sensitivity diagnostic assays requiring extreme precision, such as therapeutic drug monitoring (TDM).
• Chemical Reference Material: Acts as a certified reference material (CRM) for calibrating analytical instruments and ensuring data integrity across laboratories.

Basic Information

Item	Details
Product Name	Sodium:(2S,4S)-4-Cyclohexyl-1-[2-[Hydroxy-[4-(2,3,4,5,6-Pentadeuteriophenyl)Butyl]Phosphoryl]Acetyl]Pyrrolidine-2-Carboxylate
CAS No.	1217522-63-8
Molecular Formula	C23H30D5NNaO6P
Molecular Weight	Contact for details
Synonyms	(2S,4S)-4-Cyclohexyl-1-[2-[Hydroxy-[4-(2,3,4,5,6-Pentadeuteriophenyl)Butyl]Phosphoryl]Acetyl]Pyrrolidine-2-Carboxylic Acid Sodium Salt; Sodium 4-Cyclohexyl-1-[2-[hydroxy[4-(pentadeuteriophenyl)butyl]phosphoryl]acetyl]-L-prolinate; Deuterated Sodium Pyrrolidine Carboxylate Phosphonate Ester; [d5]-Labeled Internal Standard for [Compound X]; Stable Isotope-Labeled Analytical Standard; CAS 1217522-63-8
EINECS	Contact for details

Quality Control

Every batch of our deuterium-labeled compounds is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity as verified by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and high-resolution mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific purity, isotopic enrichment, and analytical results. Our production adheres to standards suitable for GLP and research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 98%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.