Description

(R)-2-(4-Trifluoromethyl-Phenyl)-Thiazolidine-4-Carboxylic Acid CAS NO 1217522-21-8 is a high-value, non-natural amino acid derivative featuring a chiral thiazolidine scaffold and a trifluoromethylphenyl group. This compound is a critical chiral building block and intermediate in modern pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in areas targeting metabolic and central nervous system disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, especially protease inhibitors and other enzyme-targeted therapies.
• Peptidomimetics & Constrained Peptide Design: Used to introduce conformational rigidity and metabolic stability into peptide-based drug molecules through its thiazolidine ring.
• Chemical Biology & Proteomics: Serves as a specialized building block for creating activity-based probes and chemical tools to study enzyme function and protein-protein interactions.
• Asymmetric Synthesis Catalyst Ligand: The chiral structure makes it a potential precursor for developing novel ligands used in asymmetric catalysis.
• Agrochemical Research: Employed in the discovery of new chiral active ingredients for crop protection with potentially improved efficacy and environmental profile.

Basic Information

Item	Details
Product Name	(R)-2-(4-Trifluoromethyl-Phenyl)-Thiazolidine-4-Carboxylic Acid
CAS No.	1217522-21-8
Molecular Formula	C11H10F3NO2S
Molecular Weight	277.26 g/mol
Synonyms	(R)-2-(4-(Trifluoromethyl)phenyl)thiazolidine-4-carboxylic acid; (4R)-2-[4-(Trifluoromethyl)phenyl]-1,3-thiazolidine-4-carboxylic acid; (R)-2-(p-Trifluoromethylphenyl)thiazolidine-4-carboxylic acid; (R)-TFTCA; (R)-CF3-Phenyl-Thiazolidine-Carboxylic Acid; (R)-4-Carboxy-2-(4-trifluoromethylphenyl)thiazolidine; (R)-2-(4-Trifluoromethylphenyl)thiazolidine-4-carboxylate
EINECS	Contact for details

Quality Control

Our (R)-2-(4-Trifluoromethyl-Phenyl)-Thiazolidine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.