Description

Itraconazole-D9 is a deuterated analog of the broad-spectrum antifungal agent itraconazole, specifically labeled with nine deuterium atoms. This stable isotope-labeled compound is an essential reference standard and internal standard for precise quantitative analysis in pharmaceutical research and development. It is primarily used by analytical chemists and researchers in pharmaceutical, contract research, and diagnostic laboratories for method development and validation in bioanalytical studies, particularly using LC-MS/MS techniques.

Application

• Primary use as an internal standard for the accurate quantification of itraconazole and its metabolites in biological matrices via mass spectrometry.
• Critical component in pharmacokinetic and bioequivalence studies to ensure data integrity and regulatory compliance.
• Used in method development and validation for analytical assays in pharmaceutical quality control and research laboratories.
• Reference material for doping control and forensic analysis where detection of itraconazole is required.
• Tool in drug metabolism and disposition (DMPK) studies to track and quantify the parent drug.
• Essential for clinical research involving therapeutic drug monitoring of itraconazole.

Basic Information

Product Name	Itraconazole-D9
CAS No.	1217516-26-1
Molecular Formula	C35H29D9Cl2N8O4
Molecular Weight	707.66 g/mol (deuterated form)
Synonyms	Itraconazole-d9; 4-[4-[4-[4-[[(2R*,4S*)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one-d9; Deuterated Itraconazole; Itraconazole (phenyl-d5, 1,2,4-triazolyl-d4); R 51211-d9; Sporanox-d9
EINECS	Contact for details

Quality Control

Our Itraconazole-D9 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic methods (NMR, MS) and undergoes rigorous purity analysis by HPLC. A comprehensive Certificate of Analysis (COA) is provided, detailing assay, isotopic enrichment, and impurity profiles, supporting its use in GLP and GMP-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccant use and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.