Description

Fmoc-(4S,2Rs)-2-Ethylthiazolidine-4-Carboxylic Acid is a sophisticated, non-proteinogenic amino acid derivative featuring a protected Fmoc group and a conformationally constrained thiazolidine ring. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, enabling the introduction of unique structural motifs. It is essential for researchers and manufacturers in pharmaceutical R&D, particularly those developing novel therapeutic peptides, protease inhibitors, and constrained macrocyclic compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of complex peptide sequences.
• Pharmaceutical Intermediates: Serves as a crucial chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for protease-targeted therapies.
• Peptidomimetic Design: Used to incorporate rigid, turn-inducing thiazolidine scaffolds into drug candidates to improve metabolic stability and binding affinity.
• Bioconjugation & Chemical Biology: Acts as a specialized building block for creating labeled peptides or peptide-based probes for biochemical studies.
• Academic & Industrial Research: Employed in medicinal chemistry programs exploring structure-activity relationships (SAR) in peptide-based drug discovery.

Basic Information

Product Name	Fmoc-(4S,2Rs)-2-Ethylthiazolidine-4-Carboxylic Acid
CAS No.	1217512-44-1
Molecular Formula	C₂₁H₂₁NO₄S
Molecular Weight	383.46 g/mol
Synonyms	Fmoc-(4S,2Rs)-2-ethyl-1,3-thiazolidine-4-carboxylic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-ethylthiazolidine-4-carboxylic acid; (4S,2Rs)-2-Ethyl-1,3-thiazolidine-4-carboxylic acid, N-Fmoc derivative; Fmoc-Thz(Et)-OH; Fmoc-2-ethylthiazolidine-4-carboxylic acid; N-Fmoc-2-ethyl-1,3-thiazolidine-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our Fmoc-(4S,2Rs)-2-Ethylthiazolidine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis and pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.