Description

3,5-Dimethyl-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazol-4-Ylboronic Acid is a sophisticated organoboron building block, specifically a protected pyrazole boronic acid derivative, essential for modern synthetic chemistry. Its core value lies in enabling highly selective cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental for constructing complex molecular architectures. This compound is primarily needed by pharmaceutical and agrochemical research & development teams for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing functionalized pyrazole cores.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require precise heterocyclic structures.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, ligands, and metal-organic frameworks (MOFs).
• Suzuki-Miyaura Cross-Coupling: The primary application is as a boronic acid coupling partner for forming carbon-carbon bonds with aryl or vinyl halides under palladium catalysis.
• Medicinal Chemistry: Enables the rapid exploration of structure-activity relationships (SAR) by facilitating the introduction of the pyrazole moiety into diverse molecular scaffolds.
• Process Chemistry Development: Employed in scaling up synthetic routes for commercial production, where its stability and reactivity profile are critical.

Basic Information

Product Name	3,5-Dimethyl-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazol-4-Ylboronic Acid
CAS No.	1217501-15-9
Molecular Formula	C12H19BN2O3
Molecular Weight	250.11 g/mol
Synonyms	4-Borono-3,5-dimethyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole; 1-(Tetrahydro-2H-pyran-2-yl)-3,5-dimethyl-1H-pyrazole-4-boronic acid; 3,5-Dimethyl-1-(tetrahydropyran-2-yl)-1H-pyrazole-4-boronic acid; THP-Protected 3,5-Dimethylpyrazole-4-boronic Acid; 4-Boronic acid-3,5-dimethyl-1-(tetrahydro-2-pyranyl)pyrazole; 1-(Oxan-2-yl)-3,5-dimethyl-1H-pyrazole-4-boronic acid
EINECS	Contact for details

Quality Control

Our 3,5-Dimethyl-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazol-4-Ylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, NMR, and elemental analysis to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.