Description

1-Boc-6-Bromo-Indole-2-Boronic Acid is a high-purity, multi-functional boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in the strategic combination of a protected indole nitrogen (Boc group) and a reactive boronic acid handle, enabling precise and complex molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and advanced intermediates through cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex indole-based drug candidates, especially for oncology and CNS-targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic acid functional group makes it an ideal partner for palladium-catalyzed coupling to construct biaryl and heterobiaryl structures.
• Protected Indole Chemistry: The tert-butoxycarbonyl (Boc) protecting group allows for selective functionalization at other positions of the indole ring system.
• Agrochemical Research: Used in developing new herbicides, fungicides, and insecticides that incorporate halogenated indole motifs.
• Material Science & OLED Development: Serves as a building block for creating novel organic semiconductors and light-emitting materials.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and medicinal chemistry programs.

Basic Information

Product Name	1-Boc-6-Bromo-Indole-2-Boronic Acid
CAS No.	1217500-59-8
Molecular Formula	C₁₃H₁₅BBrNO₄
Molecular Weight	340.98 g/mol
Synonyms	1-Boc-6-bromoindole-2-boronic acid; 6-Bromo-1-[(tert-butoxy)carbonyl]-1H-indole-2-boronic acid; 1-(tert-Butoxycarbonyl)-6-bromo-1H-indole-2-boronic acid; 2-Borono-6-bromo-1H-indole-1-carboxylic acid, 1,1-dimethylethyl ester; 6-Bromo-1-Boc-indole-2-boronic acid; 1-Boc-6-Br-indole-2-B(OH)₂; tert-Butyl 6-bromo-2-boronoindole-1-carboxylate
EINECS	Contact for details

Quality Control

Our 1-Boc-6-Bromo-Indole-2-Boronic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, NMR for structural confirmation, and Karl Fischer titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP compliance for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for long-term storage to maintain stability and reactivity. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Solubility Test	Conforms (DMSO, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.