Description

2-(2-Iodophenyl-D4)-N,n-Dimethylacetamide is a deuterated isotopologue of a key acetamide derivative, featuring a stable iodine atom and four deuterium atoms on the phenyl ring, making it an invaluable internal standard and tracer in advanced analytical chemistry. This high-purity compound is specifically engineered for applications requiring exceptional isotopic purity and structural specificity to ensure accurate quantification and metabolic pathway elucidation. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical, agrochemical, and analytical reagent industries for method development and regulatory compliance testing.

Application

• As a deuterated internal standard for the precise quantification of its non-deuterated counterpart in complex biological matrices using LC-MS/MS and GC-MS.
• In pharmaceutical research and development for drug metabolism and pharmacokinetics (DMPK) studies to track absorption, distribution, metabolism, and excretion (ADME).
• For the synthesis of deuterium-labeled drug candidates or advanced intermediates, leveraging the kinetic isotope effect to potentially alter metabolic profiles.
• In analytical method validation to meet stringent regulatory requirements (e.g., FDA, EMA) for accuracy, precision, and reproducibility.
• As a critical reagent in environmental fate studies and agrochemical analysis to trace the degradation and movement of chemical entities.
• Used in academic and institutional research involving mechanistic organic chemistry and isotope chemistry.

Basic Information

Product Name	2-(2-Iodophenyl-D4)-N,n-Dimethylacetamide
CAS No.	1217360-63-8
Molecular Formula	C10H8D4INO
Molecular Weight	291.13 g/mol
Synonyms	N,N-Dimethyl-2-(2-iodophenyl-d4)acetamide; 2-(2-Iodo-d4-phenyl)-N,N-dimethylacetamide; Deuterated 2-(2-Iodophenyl)-N,N-dimethylacetamide; 2-(2-Iodophenyl)-N,N-dimethylacetamide-d4; Acetamide, 2-[2-iodophenyl-d4]-N,N-dimethyl-; (2-Iodophenyl-d4)-N,N-dimethylacetamide
EINECS	Contact for details

Quality Control

Our 2-(2-Iodophenyl-D4)-N,n-Dimethylacetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and MS, to confirm chemical identity, isotopic purity (D-content), and chemical purity. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled and stored accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.