Description

2-(2-Iodophenyl-D4)Acetic Acid is a high-purity, deuterium-labeled derivative of 2-iodophenylacetic acid, serving as a critical stable isotope-labeled intermediate for advanced research and development. This compound is essential for creating internal standards in mass spectrometry, enabling precise quantification and metabolic pathway tracing in complex biological matrices. It is primarily utilized by pharmaceutical R&D teams, analytical laboratories, and contract research organizations (CROs) focused on drug metabolism and pharmacokinetics (DMPK) studies, proteomics, and environmental analysis.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of its non-labeled counterpart or related metabolites in bioanalytical assays.
• Drug Metabolism Studies (DMPK): Facilitates tracking and identification of drug metabolites in in vitro and in vivo studies to understand absorption, distribution, metabolism, and excretion (ADME).
• Proteomics & Metabolomics Research: Enables stable isotope labeling for relative and absolute quantification (SILAC/SILAQ) in mass spectrometry-based profiling.
• Synthetic Intermediate: Acts as a specialized building block for synthesizing more complex deuterium-labeled compounds for research purposes.
• Environmental Analysis: Potential use as a labeled standard for detecting and quantifying phenolic acid derivatives in environmental samples.
• Quality Control & Method Development: Supports the development and validation of robust analytical methods in regulatory and quality control laboratories.

Basic Information

Product Name	2-(2-Iodophenyl-D4)Acetic Acid
CAS No.	1217360-62-7
Molecular Formula	C8H3D4IO2
Molecular Weight	278.06 g/mol (approx.)
Synonyms	(2-Iodophenyl-D4)acetic Acid; 2-(2-Iodo-D4-phenyl)acetic Acid; Deuterated 2-Iodophenylacetic Acid; [D4]-2-(2-Iodophenyl)acetic Acid; 2-(2-Iodophenyl)acetic-2,3,4,5-d4 Acid; α-(2-Iodophenyl-D4)acetic Acid; o-Iodophenyl-D4-acetic Acid; 1217360-62-7
EINECS	Contact for details

Quality Control

Every batch of 2-(2-Iodophenyl-D4)Acetic Acid is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and isotopic enrichment meet the exacting standards required for analytical applications. Our products undergo rigorous quality testing, including NMR, HPLC, and mass spectrometry, to ensure compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing isotopic purity, chemical purity, and analytical results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.