Description

(5Z)-5-[[4-[1,1,2,2-Tetradeuterio-2-(5-Ethylpyridin-2-Yl)Ethoxy]Phenyl]Methylidene]-1,3-Thiazolidine-2,4-Dione is a deuterated analog of a thiazolidinedione derivative, a class of compounds with significant research and development interest. This compound is specifically designed for use as a stable isotope-labeled internal standard in analytical chemistry, providing superior accuracy and reliability in quantitative mass spectrometry. It is an essential tool for pharmaceutical researchers, analytical laboratories, and contract research organizations (CROs) engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical trial sample analysis.

Application

• Primary use as a stable isotope-labeled internal standard for the quantification of its non-deuterated counterpart in complex biological matrices.
• Critical component in LC-MS/MS (Liquid Chromatography-Tandem Mass Spectrometry) bioanalytical assays for drug development.
• Enabling precise pharmacokinetic (PK) and toxicokinetic (TK) studies by correcting for matrix effects and instrument variability.
• Supporting Good Laboratory Practice (GLP) and regulated bioanalysis for pre-clinical and clinical trials.
• Research into the mechanism of action and metabolic pathways of thiazolidinedione-related compounds.
• Method validation and quality control in high-throughput analytical laboratories.

Basic Information

Product Name	(5Z)-5-[[4-[1,1,2,2-Tetradeuterio-2-(5-Ethylpyridin-2-Yl)Ethoxy]Phenyl]Methylidene]-1,3-Thiazolidine-2,4-Dione
CAS No.	1217211-89-6
Molecular Formula	C19H15D4NO3S
Molecular Weight	353.46 g/mol
Synonyms	5-[[4-[1,1,2,2-Tetradeuterio-2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methylene]-2,4-thiazolidinedione; Deuterated Thiazolidinedione Derivative; d4-Thiazolidinedione Internal Standard; (5Z)-5-((4-((2-(5-Ethylpyridin-2-yl)-1,1,2,2-d4)ethoxy)benzylidene)thiazolidine-2,4-dione; 1217211-89-6; Stable Isotope Labeled Standard; Deuterated PPARγ Ligand Analog.
EINECS	Contact for details

Quality Control

This high-purity reference material is manufactured under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive analytical applications. Each lot is characterized using advanced techniques including NMR, HPLC, and mass spectrometry to confirm chemical structure, isotopic purity (D-enrichment), and chemical purity. A comprehensive Certificate of Analysis (COA) is supplied, detailing specifications for identity, purity (typically ≥95% by HPLC), and isotopic enrichment. Our quality system is designed to support GLP and research standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.